A low high density lipoprotein (HDL) level is associated with carotid artery intima-media thickness in asymptomatic members of low HDL families
| Autor: | C. Alagona, Aino Soro, Jukka T. Salonen, Riitta Salonen, Marja-Riitta Taskinen, Kati Ylitalo |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Percentile Adolescent Asymptomatic chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Humans Risk factor Aged Ultrasonography Observer Variation Cholesterol business.industry Vascular disease Cholesterol HDL Arteriosclerosis Middle Aged medicine.disease Carotid Arteries Endocrinology chemistry Intima-media thickness Cardiology lipids (amino acids peptides and proteins) medicine.symptom Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis. 165:309-316 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/s0021-9150(02)00243-5 |
| Popis: | Low serum high-density lipoprotein cholesterol (HDL-C) is a strong predictor of coronary heart disease (CHD). The aim of the present study was to evaluate the metabolic parameters predicting the atherosclerotic changes in asymptomatic members of low HDL-C families. We performed carotid B-mode ultrasonography with intima-media thickness (IMT) measurement for 89 asymptomatic members of Finnish low HDL-C families. The family members were categorized as affected or unaffected according to the 10th age-gender specific HDL-C percentile. In the affected group, the most marked decrease of HDL subclasses was observed for HDL2-C when compared with the unaffected (109% difference). In the partial correlation analyses, age and gender showed significant correlations with the mean IMT (for age, r=0.880, P |
| Databáze: | OpenAIRE |
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