Low-Frequency Transcranial Magnetic Stimulation (LF-TMS) in Treating Depression in Patients With Impaired Cognitive Functioning
| Autor: | Hamid R. Okhravi, Daniel R Schaffer, Serina A. Neumann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Vital signs Neuropsychological Tests 03 medical and health sciences 0302 clinical medicine Cognition medicine Humans 030212 general & internal medicine Cognitive skill Depression (differential diagnoses) Depressive Disorder Major business.industry Depression Beck Depression Inventory Reproducibility of Results General Medicine medicine.disease Transcranial Magnetic Stimulation Transcranial magnetic stimulation Psychiatry and Mental health Clinical Psychology Neuropsychology and Physiological Psychology Treatment Outcome Major depressive disorder business Neurocognitive 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 36(5) |
| ISSN: | 1873-5843 |
| Popis: | Objective Common methodologies for treating depressive symptoms have demonstrated decreased efficacy among individuals with impaired cognitive functioning. While transcranial magnetic stimulation (TMS) has been approved to treat major depressive disorder, few studies have analyzed the ability of TMS to treat depressive symptoms among individuals with cognitive impairments. The present study had two objectives: to determine whether low-frequency TMS (LF-TMS) might demonstrate efficacy in treating depressive symptoms among individuals with impaired cognitive functioning; and to determine whether LF-TMS might improve neurocognitive functioning above and beyond depressive symptom improvements. Methods Data were derived from a pre-existing database at Eastern Virginia Medical School. Fifty-three (N=53) participants completed LF-TMS treatment. The Beck Depression Inventory II (BDI-II) and CNS Vital Signs (CNS-VS) neurocognitive assessment were administered at multiple time points throughout treatment. Participants were classified as impaired cognitive functioning or average cognitive functioning based on baseline CNS-VS scores. Data were analyzed using restricted maximum likelihood (REML) measures-within-persons longitudinal hierarchical linear modeling (HLM) with time-varying covariates. Results LF-TMS produced significant reductions in depressive symptoms for individuals in both cognitive functioning groups; however, a significant group-by-time interaction indicates differential effects between these two groups. Low-frequency TMS produced significant improvements in three neurocognitive domains above and beyond improvements in depressive symptoms; however, the reliability of these changes may be questionable. Conclusions This study adds to the growing body of empirical findings for LF-TMS treatment in improving neurocognitive functioning above and beyond other treatment-related effects. |
| Databáze: | OpenAIRE |
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