Gain of chromosome 2p in chronic lymphocytic leukemia: significant heterogeneity and a new recurrent dicentric rearrangement
| Autor: | Tomas Papajik, Radek Plachy, Helena Urbankova, Marie Jarošová, Jana Balcarkova, Z. Pikalová, Vladimir Divoky, Milena Holzerova, Karel Indrak |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cancer Research Chronic lymphocytic leukemia Centromere Biology Dicentric chromosome Genetic Heterogeneity hemic and lymphatic diseases medicine Humans neoplasms Gene In Situ Hybridization Fluorescence Aged Chromosome Aberrations Comparative Genomic Hybridization medicine.diagnostic_test Genetic heterogeneity Chromosome Karyotype Hematology Middle Aged medicine.disease Molecular biology Leukemia Lymphocytic Chronic B-Cell Oncology Chromosomes Human Pair 2 Karyotyping Cancer research Female Fluorescence in situ hybridization Comparative genomic hybridization |
| Zdroj: | Leukemialymphoma. 51(2) |
| ISSN: | 1029-2403 |
| Popis: | Array-based comparative genomic hybridization (arrayCGH) studies in chronic lymphocytic leukemia (CLL) have revealed novel recurrent chromosomal imbalances, such as a gain of chromosome 2p. However, a detailed cytogenetic analysis of the 2p gain region has not been elucidated. Here, we present cytogenetic and molecular cytogenetic analysis of 16 such cases selected from a group of 200 patients with CLL based on CGH and/or arrayCGH data. We revealed significant heterogeneity of the region of gain on 2p in CLL, including a new recurrent aberration: the dicentric chromosome, dic(2;18). In our cases, the region of gain involved three genes (MYCN, REL, and ALK) and was associated with an unmutated IgVH status in 14 out of 16 cases. We consider this aberration clinically important in CLL and suggest that an examination of the gene(s) located in region of gain should be included in the routine fluorescence in situ hybridization screening method used for patients with CLL. |
| Databáze: | OpenAIRE |
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