Blood levels of microRNAs associated with ischemic heart disease differ between Austrians and Japanese: a pilot study
| Autor: | Yoko Sotoda, Ryoji Eguchi, Dirk von Lewinski, Ichiro Wakabayashi, Peter P. Rainer, Klaus Groschner, Takashi Daimon, Harald Sourij |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Vascular smooth muscle Myocardial Ischemia Physiology lcsh:Medicine Differentially expressed mirnas Pilot Projects Disease Article Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Japan microRNA Biomarkers Tumor Medicine Humans Circulating MicroRNA lcsh:Science Multidisciplinary business.industry Gene Expression Profiling lcsh:R Middle Aged Pathway analysis Prognosis 030104 developmental biology Cardiovascular diseases Risk factors Austria Case-Control Studies lcsh:Q Ischemic heart business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-69332-0 |
| Popis: | Mortality from ischemic heart disease (IHD) is significantly lower in Japan than in Western countries. The purpose of this study was to investigate differences in circulating microRNA (miRNA) levels related to IHD in Austrians and Japanese. Participants were middle-aged healthy male Austrians (n = 20) and Japanese (n = 20). Total miRNAs in serum from each participant were analyzed using the 3D-Gene miRNA Oligo chip. Twenty-one miRNAs, previously reported as associated with IHD, were compared between Austrians and Japanese. The expression levels of miR-106a-5p, miR-135a-3p, miR-150-3p, miR-16-5p, miR-17-5p. miR-191-5p, miR-320b, miR-451a, miR-486-5p, miR-663b, and miR-92a-3p were significantly higher, while the miR-2861 expression level was significantly lower in Austrians as compared to Japanese. Both in Austrians and Japanese, there were significant positive correlations between serum expression levels of each pair of the above miRNAs except for miR-2861. The expression level of miR-2861 showed significant positive correlations with the expression levels of miR-106a-5p, miR-150-3p, miR-17-5p, miR-486-5p, miR-663b and miR-92a-3p in Austrians but not in Japanese. In pathway analysis, proinflammatory cytokine production in foam cells and collagen synthesis in vascular smooth muscle cells were associated with differentially expressed miRNAs. Difference in miRNA levels may contribute to lower cardiovascular risk in Japan than in Western countries. |
| Databáze: | OpenAIRE |
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