The pre-vertebrate origins of neurogenic placodes
| Autor: | T. Blair Gainous, Christopher J. Winchell, Clare Hudson, Masashi Nakagawa, Philip B. Abitua, Takehiro Kusakabe, Motoyuki Tsuda, Kaori Kamata, Michael Levine, Angela N. Kaczmarczyk |
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| Přispěvatelé: | Laboratoire de Biologie du Développement de Villefranche sur mer (LBDV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Biology, Faculty of Science and Engineering, Konan University |
| Rok vydání: | 2015 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Neurogenic placodes Molecular Sequence Data Article Receptors G-Protein-Coupled Gonadotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine biology.animal Ectoderm Animals Humans Ciona intestinalis [SDV.BDD]Life Sciences [q-bio]/Development Biology ComputingMilieux_MISCELLANEOUS Body Patterning 030304 developmental biology Homeodomain Proteins Neurons 0303 health sciences Multidisciplinary biology Extramural Intracellular Signaling Peptides and Proteins Vertebrate Anatomy biology.organism_classification Closest relatives Tunicate HEK293 Cells Larva Bone Morphogenetic Proteins Vertebrates Evolutionary developmental biology Protein Tyrosine Phosphatases 030217 neurology & neurosurgery |
| Zdroj: | Nature Nature, Nature Publishing Group, 2015, 524 (7566), pp.462-465. ⟨10.1038/nature14657⟩ |
| ISSN: | 1476-4687 0028-0836 1476-4679 |
| DOI: | 10.1038/nature14657 |
| Popis: | The sudden appearance of the neural crest and neurogenic placodes in early branching vertebrates has puzzled biologists for over a century. These embryonic tissues contribute to the development of the cranium and associated sensory organs, which were crucial for the evolution of the vertebrate "new head". A previous study suggests that rudimentary neural crest cells existed in ancestral chordates. However, the evolutionary origins of neurogenic placodes have remained obscure owing to a paucity of embryonic data from tunicates, the closest living relatives to those early vertebrates. Here we show that the tunicate Ciona intestinalis exhibits a proto-placodal ectoderm (PPE) that requires inhibition of bone morphogenetic protein (BMP) and expresses the key regulatory determinant Six1/2 and its co-factor Eya, a developmental process conserved across vertebrates. The Ciona PPE is shown to produce ciliated neurons that express genes for gonadotropin-releasing hormone (GnRH), a G-protein-coupled receptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests dual chemosensory and neurosecretory activities. These observations provide evidence that Ciona has a neurogenic proto-placode, which forms neurons that appear to be related to those derived from the olfactory placode and hypothalamic neurons of vertebrates. We discuss the possibility that the PPE-derived GnRH neurons of Ciona resemble an ancestral cell type, a progenitor to the complex neuronal circuit that integrates sensory information and neuroendocrine functions in vertebrates. |
| Databáze: | OpenAIRE |
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