Polymorphisms of Interleukin-6 and Tumor Necrosis Factor Gene Promoters and Cardiorespiratory Function Following Liver Transplantation: A Preliminary Study
| Autor: | J. Arranz Duran, C. Flores, A. Soriano Benítez de Lugo, A. González, S. Méndez Alvárez, I. García Cobaleda, F.J. González-Paredes, I. Arteaga González, P. Sanz Pereda, A. Varona Bosque, R. Calvo Falcón, D. Domínguez García, M. Barrera Gómez, A. Aguirre Jaime |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Liver transplantation Polymerase Chain Reaction Gastroenterology Internal medicine medicine Humans Respiratory function Promoter Regions Genetic Interleukin 6 Gene Retrospective Studies Analysis of Variance Transplantation Chi-Square Distribution Polymorphism Genetic biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Promoter Cardiorespiratory fitness Length of Stay Liver Transplantation Respiratory Function Tests Treatment Outcome surgical procedures operative Heart Function Tests Immunology biology.protein Surgery Tumor necrosis factor alpha Analysis of variance business Polymorphism Restriction Fragment Length |
| Zdroj: | Transplantation Proceedings. 41:1062-1064 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2009.02.035 |
| Popis: | Introduction. The interindividual variability in cardiorespiratory function during liver transplantation (OLT) has been attributed to various factors, including polymorphisms in immunity genes known to affect the circulation levels of cytokines. Aim. To evaluate polymorphisms of genes encoding for interleukin-6 (IL6) and tumor necrosis factor (TNF) in association with cardiorespiratory function in OLT. Design. Prospective observational study. Patients and methods. We studied 62 consecutive patients who had OLT performed in our hospital between 2004 and 2005. Polymorphisms at positions -308 and -409 of TNF gene, as well as those at -174 and -574 of IL6 gene were determined in all patients by means of PCR-RFLPs. Associations were carried out using chi-square tests and analysis of variance. A bilateral P |
| Databáze: | OpenAIRE |
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