Clinical relevance of Alternaria alternata sensitization in patients within type 2-high and type 2-low asthma
| Autor: | Jun-Da Li, Jia Yin, Juan Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Allergen immunotherapy medicine.medical_specialty Adolescent Immunology Immunoglobulin E medicine.disease_cause Alternaria alternata Gastroenterology Young Adult Allergen Internal medicine Hypersensitivity medicine Humans Immunology and Allergy Child Sensitization Aged Retrospective Studies Skin Tests Asthma Pharmacology biology business.industry Patient Acuity Alternaria Infant Allergens Middle Aged Eosinophil medicine.disease biology.organism_classification medicine.anatomical_structure Child Preschool biology.protein Female business |
| Zdroj: | International Immunopharmacology. 101:108333 |
| ISSN: | 1567-5769 |
| Popis: | Alternaria sensitization is correlated with persistent asthma. Type 2 (T2)-asthma endotypes are characterized by the release of eosinophils. However, the prevalence and sensitization patterns in patients with Alternaria asthma between T2-high and T2-low endotypes are unknown. We retrospectively reviewed 582 patients with Alternaria asthma and divided them into T2-high (n = 376) and T2-low (n = 206) groups with a threshold of 300 cells/µL in blood eosinophil counts. Data for basic information, skin test or IgE detection results, and blood eosinophil counts were collected. The age of patients in the T2-high group (13.66 ± 13.23) was lower than that of the T2-low group (18.02 ± 15.03). Patients with T2-high asthma had relatively higher rates of taking inhaled corticosteroids (ICS) and positive family history than the T2-low group. Pet keepers and allergen immunotherapy (AIT) patients were comparable between these groups, In the T2-high group, patients had higher levels of total serum IgE (T-IgE) and showed a significant positive correlation with eosinophil counts (r = 0.166, P = 0.001), followed by higher Alternaria-specific IgE (sIgE) levels (median, 13.7; range, 4.86-25.3). Compared to the T2-low group, the frequency of poly-sensitized patients and the rate of each allergen among the nine common allergens were all higher in the T2-high group; the statistical differences mainly focused on pollens such as birch (P = 0.005), firmiana (P = 0.004), and mugwort (P = 0.005). Young, male patients had a high prevalence of T2-high Alternaria asthma, along with higher rates of T-IgE, sIgE levels, and poly-sensitized patterns. |
| Databáze: | OpenAIRE |
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