Sustained clearance of Mansonella ozzardi infection after treatment with ivermectin in the Brazilian Amazon
| Autor: | Sergio de Almeida Basano, Pedro di Tárique Barreto Crispim, Jansen Fernandes Medeiros, Luis Marcelo Aranha Camargo, Ricardo de Godoi Mattos Ferreira, Juliana Souza de Almeida Aranha Camargo, Luana Janaína Souza Vera, Marcos Paulo Parente Araújo, Gilberto Fontes, Maira Santiago Pires Parente |
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| Rok vydání: | 2014 |
| Předmět: |
Drug
Adult Male Rural Population food.ingredient Adolescent media_common.quotation_subject Physiology NEMATOIDES Parasitemia Pharmacology Young Adult Mansonella Ozzardi Infection Ivermectin food Virology parasitic diseases medicine Mansonelliasis Animals Humans Child Microfilariae media_common Hematologic Tests biology Antiparasitic Agents business.industry Articles Mansonella Middle Aged medicine.disease biology.organism_classification Antiparasitic agent Infectious Diseases Treatment Outcome Child Preschool Parasitology Female Mansonella ozzardi business Brazil medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1476-1645 |
| Popis: | Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Labrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level. |
| Databáze: | OpenAIRE |
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