Tofacitinib for the treatment of refractory pyoderma gangrenosum
| Autor: | S. N. Tolkachjov, V. E. Orfaly, Alex G. Ortega-Loayza, J. R. Nunley, I. Kovalenko |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty medicine.medical_treatment media_common.quotation_subject Context (language use) Dermatology Leg Dermatoses Inflammatory bowel disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Refractory Piperidines medicine Humans Protein Kinase Inhibitors media_common Aged Aged 80 and over Tofacitinib business.industry Surgical Stomas Middle Aged medicine.disease Inflammatory Bowel Diseases Comorbidity Pyoderma Gangrenosum Pyrimidines Treatment Outcome 030220 oncology & carcinogenesis Female Dermatologic Agents business Adjuvant Pyoderma gangrenosum Immunosuppressive Agents |
| Zdroj: | Clinical and experimental dermatologyReferences. 46(6) |
| ISSN: | 1365-2230 |
| Popis: | Pyoderma gangrenosum (PG) is a rare, debilitating, inflammatory skin disease associated with a variety of systemic diseases. Because of its rarity, PG is treated with miscellaneous immunosuppressive agents as there is no US Food and Drug Administration-approved standardized treatment approach. We present four patients with PG treated with tofacitinib in the context of the six existing cases in the literature. Tofacitinib appeared to be beneficial in the small sample of patients (n = 10) who failed an average of four other systemic therapies. The majority of patients had classic PG located on the legs (80%, 8/10), while 20% of cases (2/10) were peristomal. The most common comorbidity was inflammatory bowel disease (78%, 7/9). There were no negative treatment results and 40% (4/10) of patients had complete healing of their ulcers, while the other 60% (6/10) had marked clinical improvement. From our observation, tofacitinib appears to be a promising steroid-sparing adjuvant treatment in patients with refractory PG who have failed on other systemic therapies. |
| Databáze: | OpenAIRE |
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