Effectiveness of pneumococcal Haemophilus influenzae protein D conjugate vaccine against pneumonia in children: A cluster-randomised trial
| Autor: | Lode Schuerman, Hanna Rinta-Kokko, Marta Moreira, Esa Ruokokoski, A. A. Palmu, T. Puumalainen, Dorota Borys, Patricia Lommel, Jukka Jokinen, Magali Traskine, Heta Nieminen, Terhi Kilpi, Javier Ruiz-Guiñazú |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Vaccination schedule Lipoproteins 030231 tropical medicine Rate ratio medicine.disease_cause Pneumococcal Infections Haemophilus influenzae Pneumococcal Vaccines 03 medical and health sciences 0302 clinical medicine Bacterial Proteins Double-Blind Method Internal medicine medicine Humans 030212 general & internal medicine Hepatitis vaccine Finland Immunization Schedule General Veterinary General Immunology and Microbiology business.industry Public Health Environmental and Occupational Health Vaccine trial Infant Immunoglobulin D Pneumonia medicine.disease Vaccination Otitis Media Infectious Diseases Otitis Molecular Medicine Female medicine.symptom Carrier Proteins business |
| Zdroj: | Vaccine. 36:5891-5901 |
| ISSN: | 0264-410X |
| Popis: | BACKGROUND Pneumococcal conjugate vaccines have potential to prevent significant proportion of childhood pneumonia. Finnish Invasive Pneumococcal disease vaccine trial was designed to assess the vaccine effectiveness (VE) of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against several outcomes. We now report results for pneumonia. METHODS In this nationwide, cluster-randomised, double-blind trial, children younger than 19 months received PHiD-CV10 in 52 clusters or hepatitis vaccines as control in 26 clusters. Infants younger than 7 months at the first vaccination received either 3+1 or 2+1 vaccination schedule, children aged 7-11 months received 2+1, and those 12-18 months of age two-dose schedule. All hospitalizations and outpatient visits to hospital associated with ICD-10 codes compatible with pneumonia were identified through the National Care Register and 1-3 frontal chest X-ray images per event were collected. External readers who were unaware of the patients' vaccination status retrospectively interpreted the images. The evaluated outcomes were hospital-diagnosed, hospital-treated pneumonia as primary diagnosis, and radiologically confirmed pneumonia during the blinded, intention-to-treat follow-up period from the first vaccination to the end of 2011. Total VE was calculated as 1 minus rate ratio of all pneumonia episodes. RESULTS 47 366 children were enrolled from February 2009, to October 2010. VE against all episodes of hospital-diagnosed pneumonia was 27% (95% confidence interval [CI]: 14%, 38%), 32% (95% CI: 3%, 52%), and 23% (95% CI: -5%, 44%) in subjects enrolled at age |
| Databáze: | OpenAIRE |
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