Let-7a-5p, miR-100-5p, miR-101-3p, and miR-199a-3p Hyperexpression as Potential Predictive Biomarkers in Early Breast Cancer Patients
| Autor: | Antonino Mulè, Giovanni Scambia, Ettore Capoluongo, Giampaolo Tortora, Chiara Autilio, Alejandro Martin Sanchez, Gianluca Franceschini, Brunella Di Stefano, Antonina Rinninella, Flavio Mignone, Mariantonietta Di Salvatore, Concetta Santonocito, Nicola Nicolotti, Carlo Barone, Alessandra Cassano, Armando Orlandi, Matteo Ramundo, Donatella Guarino, Damiano Arciuolo, Paola Fuso |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment precision medicine Medicine (miscellaneous) chemotherapy Article Oncología Breast cancer Internal medicine microRNA medicine integrated therapies Next‐generation‐sequencing Predictive biomarker Early breast cancer Chemotherapy Settore MED/06 - ONCOLOGIA MEDICA business.industry target therapy Mir 101 3p personalized medicine next-generation-sequencing medicine.disease breast cancer treatment Integrated ther-apies miRNAs Medicine Personalized medicine subtypes breast cancer business Mir 199a 3p |
| Zdroj: | Journal of Personalized Medicine E-Prints Complutense. Archivo Institucional de la UCM Universidad Europea (UEM) Volume 11 Issue 8 Journal of Personalized Medicine, Vol 11, Iss 816, p 816 (2021) |
| Popis: | Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC). Patients and methods: We retrospectively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next-Generation-Sequencing (NGS) system. Results: Event-free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let-7a-5p (EFS p = 0.006 OS p = 0.0001), mirR-100-5p (EFS s p = 0.01 OS p = 0.03), miR-101-3p (EFS p = 0.05 OS p = 0.01), and miR-199a-3p (EFS p = 0.02 OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let-7a-5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up-regulation of the above miRNAs could represent biomarkers in breast cancer. |
| Databáze: | OpenAIRE |
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