Influence of repeated vitamin B administration on the frequency pattern analysed from rat brain electrical activity (tele-stereo-EEG)

Autor: D. Bonke, W. Dimpfel, M. Spüler
Rok vydání: 1990
Předmět:
Zdroj: Klinische Wochenschrift. 68:136-141
ISSN: 1432-1440
0023-2173
DOI: 10.1007/bf01646862
Popis: Recording of field potentials from different brain areas of freely behaving rats and subsequent spectral analysis of the signals has proved to be a most sensitive method in pharmacology. This new model is used to measure the effect on the electrical activity of the brain of repeated daily injections of 1 ml/kg of a vitamin B mixture (Neurobion, 1 ml containing 33.3 mg B1, 33.3 mg B6, and 0.333 mg B12). Subacute application of the vitamin B combination for 1 week in a group of six rats resulted in changes in the power spectra, which became more prominent from day to day. Particularly increases in the power of the alpha 1 and beta range from the thalamus dominated the vitamin-induced changes. From the comparison with earlier results obtained with centrally acting serotonergic drugs, it is concluded that the pharmacodynamic action of the vitamin B mixture predominantly influences this transmitter system. The same group of animals, once challenged with a single dose of 0.2 mg/kg morphine before the repeated vitamin treatment, responded to the same challenge after the treatment in a more sensitive manner. Particularly power changes in the beta range were more pronounced. This higher sensitivity to a morphine challenge persisted for more than 1 week after the end of the vitamin treatment which points to a plastic change in serotonergic neurotransmitter control processes. The results obtained here may be linked to the antinociceptive properties of the vitamin B mixture and practical consequences may include a reduction of morphine dose for analgesia during repeated vitamin B treatment.
Databáze: OpenAIRE
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