The cardiac isovolumetric contraction time is an independent predictor of incident atrial fibrillation and adverse outcomes following first atrial fibrillation event in the general population
Autor: | Jan Skov Jensen, Alia Saed Alhakak, Rasmus Mogelvang, Gorm B. Jensen, Tor Biering-Sørensen, Philip Brainin |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Population 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Atrial Fibrillation Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies 030212 general & internal medicine education Stroke education.field_of_study business.industry Hazard ratio Stroke Volume Atrial fibrillation General Medicine Stroke volume medicine.disease Myocardial Contraction Echocardiography Doppler Confidence interval Heart failure Cardiology Cardiology and Cardiovascular Medicine Isovolumic relaxation time business |
Zdroj: | European Heart Journal - Cardiovascular Imaging. 21:49-57 |
ISSN: | 2047-2412 2047-2404 |
Popis: | Aims Colour tissue Doppler imaging (TDI) M-mode through the mitral leaflet is an easy and precise method to obtain cardiac time intervals including the isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT), and ejection time (ET). The myocardial performance index (MPI) was defined as [(IVCT + IVRT)/ET]. Our aim was to investigate if cardiac time intervals can be used to predict atrial fibrillation (AF) in the general population. Methods and results A total of 1915 participants from the general population underwent a health examination including TDI echocardiography. The primary endpoint was AF, and the secondary endpoint was complicated AF as assessed by the occurrence of either stroke or heart failure (HF) after the diagnosis of AF. Participants with known AF were excluded (n = 54). During a median follow-up of 11 years, 166 participants (9%) were diagnosed with AF and of these 44 participants (27%) developed HF or stroke. Assessing the association between IVCT and incident AF, the risk increased with 27% per 10 ms increase in IVCT [per 10 ms increase: hazard ratio (HR) 1.27, 95% confidence interval (CI) (1.17–1.38); P Conclusion In the general population, the IVCT provides novel and independent prognostic information on the long-term risk of AF. Additionally, the IVCT can identify persons in risk of complicated AF. |
Databáze: | OpenAIRE |
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