Anticancer Potential of Sutherlandia frutescens and Xysmalobium undulatum in LS180 Colorectal Cancer Mini-Tumors
| Autor: | Clarissa Willers, Krzysztof Wrzesinski, Tanya Smit, Hanna Svitina, Carlemi Calitz, Chrisna Gouws |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
three-dimensional cell culture
Colorectal cancer Cell Xysmalobium undulatum Pharmaceutical Science colorectal cancer Pharmacology anticancer Analytical Chemistry sodium alginate lcsh:QD241-441 03 medical and health sciences Phytomedicine chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry phytomedicine Drug Discovery functional spheroids Medicine Viability assay Physical and Theoretical Chemistry Medicinal plants 030304 developmental biology 0303 health sciences Cancer och onkologi Sutherlandia frutescens biology business.industry Organic Chemistry Cancer medicine.disease biology.organism_classification medicine.anatomical_structure Paclitaxel chemistry Chemistry (miscellaneous) 030220 oncology & carcinogenesis Cancer and Oncology Molecular Medicine business |
| Zdroj: | Molecules, Vol 26, Iss 605, p 605 (2021) Molecules Volume 26 Issue 3 |
| Popis: | Colorectal cancer remains to be one of the leading causes of death worldwide, with millions of patients diagnosed each year. Although chemotherapeutic drugs are routinely used to treat cancer, these treatments have severe side effects. As a result, the use of herbal medicines has gained increasing popularity as a treatment for cancer. In this study, two South African medicinal plants widely used to treat various diseases, Sutherlandia frutescens and Xysmalobium undulatum, were evaluated for potential activity against colorectal cancer. This potential activity for the treatment of colorectal cancer was assessed relative to the known chemotherapeutic drug, paclitaxel. The cytotoxic activity was considered in an advanced three-dimensional (3D) sodium alginate encapsulated LS180 colorectal cancer functional spheroid model, cultured in clinostat-based rotating bioreactors. The LS180 cell mini-tumors were treated for 96 h with two concentrations of each of the crude aqueous extracts or paclitaxel. S. frutescens extract markedly decreased the soluble protein content, while decreasing ATP and AK per protein content to below detectable limits after only 24 h exposure. X. undulatum extract also decreased the soluble protein content, cell viability, and glucose consumption. The results suggested that the two phytomedicines have potential to become a source of new treatments against colorectal cancer. |
| Databáze: | OpenAIRE |
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