Effects of molybdenum on sperm quality and testis oxidative stress
| Autor: | Qiao Qi, Zi-Jun Yang, Xiao-Wei Zhai, Yu-Ling Zhang, Xue-Gang Ma, Runzhe Shu, Xiao-Li Chen, Feng-Jun Liu, Li-Jun Jin, Yu Bai |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Urology Biology Semen analysis medicine.disease_cause Superoxide dismutase Mice chemistry.chemical_compound Malondialdehyde Internal medicine Testis medicine Animals reproductive and urinary physiology Sperm motility Epididymis Molybdenum chemistry.chemical_classification Glutathione Peroxidase Mice Inbred ICR Sperm Count medicine.diagnostic_test Superoxide Dismutase urogenital system Glutathione peroxidase Sperm Semen Analysis Oxidative Stress Endocrinology medicine.anatomical_structure Reproductive Medicine chemistry Sperm Motility biology.protein Oxidative stress |
| Zdroj: | Systems Biology in Reproductive Medicine. 59:251-255 |
| ISSN: | 1939-6376 1939-6368 |
| Popis: | In order to investigate the effects of molybdenum (Mo) on sperm parameters and testicular oxidative stress, the ICR strain of adult mice were exposed to different doses of molybdenum for a sub-acute toxicity test. Compared to the control, our results showed that the sperm parameters, including the epididymis index, sperm motility, sperm count, and morphology, increased by a moderate dose of Mo (25 mg/L), but were negatively affected at high doses (≥ 100 mg/L). In addition, the changes of sperm parameters were accompanied with changes of the superoxide dismutase (SOD) activities, the glutathione peroxidase (GPx) activities, and the malondialdehyde (MDA) levels in testes. In conclusion, Mo affects the sperm quality through regulating the testicular oxidative stress in a complex manner. |
| Databáze: | OpenAIRE |
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