Formulation and in vitro evaluation of topical nanosponge-based gel containing butenafine for the treatment of fungal skin infection
| Autor: | Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Mohd Abul Kalam, Elmutasim O. Ibnouf, Ahmed Alalaiwe, Md. Khalid Anwer, Farhat Fatima, Mohammad Javed Ansari, Aws Alshamsan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nanosponges
Butenafine Antifungal study Dispersity Pharmaceutical Science 02 engineering and technology Topical gel RM1-950 030226 pharmacology & pharmacy Polyvinyl alcohol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pulmonary surfactant Ethyl cellulose medicine Zeta potential Pharmacology Flux Chemistry 021001 nanoscience & nanotechnology In-vitro diffusion Solvent Original Article Particle size Therapeutics. Pharmacology 0210 nano-technology Nuclear chemistry medicine.drug |
| Zdroj: | Saudi Pharmaceutical Journal, Vol 29, Iss 5, Pp 467-477 (2021) Saudi Pharmaceutical Journal : SPJ |
| ISSN: | 1319-0164 |
| Popis: | In the current study, four formulae (BNS1-BNS4) of butenafine (BTF) loaded nanosponges (NS) were fabricated by solvent emulsification technology, using different concentration of ethyl cellulose (EC) and polyvinyl alcohol (PVA) as a rate retarding polymer and surfactant, respectively. Prepared NS were characterized for particle size (PS), polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE) and drug loading (DL). Nanocarrier BNS3 was optimized based on the particle characterizations and drug encapsulation. It was further evaluated for physicochemical characterizations; FTIR, DSC, XRD and SEM. Selected NS BNS3 composed of BTF (100 mg), EC (200 mg) and 0.3% of PVA showed, PS (543 ± 0.67 nm), PDI (0.330 ± 0.02), ZP (−33.8 ± 0.89 mV), %EE (71.3 ± 0.34%) and %DL (22.8 ± 0.67%), respectively. Fabricated NS also revealed; polymer-drug compatibility, drug-encapsulation, non-crystalline state of the drug in the spherical NS as per the physicochemical evaluations. Optimized NS (BNS3) with equivalent amount of (1%, w/w or w/v) BTF was incorporated into the (1%, w/w or w/v) carbopol gel. BTF loaded NS based gel was then evaluated for viscosity, spreadability, flux, drug diffusion, antifungal, stability and skin irritation studies. BNS3 based topical gels exhibited a flux rate of 0.18 (mg/cm2.h), drug diffusion of 89.90 ± 0.87% in 24 h with Higuchi model following anomalous non-Fickian drug release. The BNS3 based-gel could be effective against pathogenic fungal strains. |
| Databáze: | OpenAIRE |
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