MicroRNAs are indispensable for the proliferation and differentiation of adult neural progenitor cells in mice
| Autor: | Jan Rodriguez Parkitna, Karolina Hajdukiewicz, Anshul Tiwari, Joanna Przybyś, Martin Novak, Ilya A. Vinnikov, Yang Xu, Witold Konopka, Günther Schütz |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Ribonuclease III Neurogenesis Central nervous system Biophysics Subventricular zone Biochemistry DEAD-box RNA Helicases 03 medical and health sciences Mice 0302 clinical medicine Neural Stem Cells RNA interference Lateral Ventricles microRNA medicine Animals Molecular Biology Cells Cultured Cell Proliferation biology Gene Expression Regulation Developmental Cell Biology Neural stem cell Adult Stem Cells MicroRNAs 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein DICER1 Gene Female Transcriptome Neuroscience Dicer |
| Zdroj: | Biochemical and biophysical research communications. 530(1) |
| ISSN: | 1090-2104 |
| Popis: | More than two decades after the discovery of adult neurogenesis in humans, researchers still struggle to elucidate the underlying transcriptional and post-transcriptional mechanisms. RNA interference is a crucially important process in the central nervous system, and its role in adult neurogenesis is poorly understood. In this work, we address the role of Dicer-dependent microRNA biogenesis in neuronal differentiation of adult neural stem cells within the subventricular zone of the mouse brain. Loss of the Dicer1 gene in the tailless (Tlx)-positive cells did not cause the decline in their numbers, but severely affected differentiation. Thus, our findings identify yet another phenomenon associated with microRNA pathway deregulation in adult neural stem cells which might be of relevance both for neuroscience and clinical practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect