Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer
Autor: | Witold Kot, Morten Kobaek-Larsen, Dennis Sandris Nielsen, Lars Porskjær Christensen, Gunnar Baatrup, Łukasz Krych |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male Colorectal cancer Denmark Physiology lcsh:Medicine Falcarinol Gut flora chemistry.chemical_compound Cecum Carrots RNA Ribosomal 16S Gastrointestinal Microbiome/drug effects lcsh:QH301-705.5 biology Microbiota Colorectal Neoplasms/drug therapy General Medicine Fatty Alcohols/pharmacology Research Note medicine.anatomical_structure Rat model Large Colon Fatty Alcohols Colorectal Neoplasms Diynes/pharmacology 030106 microbiology digestive system General Biochemistry Genetics and Molecular Biology Diynes 03 medical and health sciences Falcarindiol medicine Animals lcsh:Science (General) Feces Azoxymethane lcsh:R Polyynes medicine.disease biology.organism_classification Rats Inbred F344 Gastrointestinal Microbiome Diet Rats stomatognathic diseases 030104 developmental biology chemistry lcsh:Biology (General) Colon neoplasm Polyacetylenes lcsh:Q1-390 |
Zdroj: | BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018) Kobaek-Larsen, M, Nielsen, D S, Kot, W, Krych, L, Christensen, L P & Baatrup, G 2018, ' Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer ', BMC Research Notes, vol. 11, 411, pp. 1-6 . https://doi.org/10.1186/s13104-018-3527-y Kobaek-Larsen, M, Nielsen, D S, Kot, W, Krych, Ł, Christensen, L P & Baatrup, G 2018, ' Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer ', BMC Research Notes, vol. 11, 411 . https://doi.org/10.1186/s13104-018-3527-y Kobæk Larsen, M, Nielsen, D S, Kot, W, Krych, L, Christensen, L P & Baatrup, G 2018, ' Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer ', BMC Research Notes, vol. 11, no. 1, 411, pp. 1-6 . https://doi.org/10.1186/s13104-018-3527-y BMC Research Notes Kobaek-Larsen, M, Nielsen, D S, Kot, W, Krych, Ł, Christensen, L P & Baatrup, G 2018, ' Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer ', BMC Research Notes, vol. 11, no. 1, 411 . https://doi.org/10.1186/s13104-018-3527-y |
ISSN: | 1756-0500 |
Popis: | Objectives: (3R)-Falcarinol (FaOH) and (3R,8S)-falcarindiol (FaDOH) have previously been shown to reduce the number of neoplastic lesions and the growth rate of polyps in the colon of azoxymethane (AOM) treated rats. Based on previous investigations, it appears that different mechanisms of actions are involved in the antineoplastic effect of FaOH and FaDOH. One mechanism of action may be related to the antibacterial effect of FaOH and FaDOH and thus their effect on the gut microbiota. This study aimed to determine the effect of FaOH and FaDOH on gut microbiota composition of AOM treated rats. Results: Azoxymethane treated rats were fed either a standard rat diet or a rat diet supplemented with FaOH and FaDOH. The gut microbiota of AOM-induced rats was determined by 16S rRNA gene-amplicon sequencing. Analysis of fecal cecum samples demonstrated a significant gut microbiota change in rats receiving standard rat diet supplemented with FaOH and FaDOH compared with the control group that only received the rat diet. Comparison of the gut microbiota of rats who developed large neoplasms in the colon with rats without large neoplasms showed that the gut microbiota was significantly different in rats who developed large colon neoplasms compared to rats with no macroscopic colon neoplasms. |
Databáze: | OpenAIRE |
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