Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer

Autor: Witold Kot, Morten Kobaek-Larsen, Dennis Sandris Nielsen, Lars Porskjær Christensen, Gunnar Baatrup, Łukasz Krych
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Colorectal cancer
Denmark
Physiology
lcsh:Medicine
Falcarinol
Gut flora
chemistry.chemical_compound
Cecum
Carrots
RNA
Ribosomal
16S
Gastrointestinal Microbiome/drug effects
lcsh:QH301-705.5
biology
Microbiota
Colorectal Neoplasms/drug therapy
General Medicine
Fatty Alcohols/pharmacology
Research Note
medicine.anatomical_structure
Rat model
Large Colon
Fatty Alcohols
Colorectal Neoplasms
Diynes/pharmacology
030106 microbiology
digestive system
General Biochemistry
Genetics and Molecular Biology
Diynes
03 medical and health sciences
Falcarindiol
medicine
Animals
lcsh:Science (General)
Feces
Azoxymethane
lcsh:R
Polyynes
medicine.disease
biology.organism_classification
Rats
Inbred F344
Gastrointestinal Microbiome
Diet
Rats
stomatognathic diseases
030104 developmental biology
chemistry
lcsh:Biology (General)
Colon neoplasm
Polyacetylenes
lcsh:Q1-390
Zdroj: BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
Kobaek-Larsen, M, Nielsen, D S, Kot, W, Krych, L, Christensen, L P & Baatrup, G 2018, ' Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer ', BMC Research Notes, vol. 11, 411, pp. 1-6 . https://doi.org/10.1186/s13104-018-3527-y
Kobaek-Larsen, M, Nielsen, D S, Kot, W, Krych, Ł, Christensen, L P & Baatrup, G 2018, ' Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer ', BMC Research Notes, vol. 11, 411 . https://doi.org/10.1186/s13104-018-3527-y
Kobæk Larsen, M, Nielsen, D S, Kot, W, Krych, L, Christensen, L P & Baatrup, G 2018, ' Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer ', BMC Research Notes, vol. 11, no. 1, 411, pp. 1-6 . https://doi.org/10.1186/s13104-018-3527-y
BMC Research Notes
Kobaek-Larsen, M, Nielsen, D S, Kot, W, Krych, Ł, Christensen, L P & Baatrup, G 2018, ' Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer ', BMC Research Notes, vol. 11, no. 1, 411 . https://doi.org/10.1186/s13104-018-3527-y
ISSN: 1756-0500
Popis: Objectives: (3R)-Falcarinol (FaOH) and (3R,8S)-falcarindiol (FaDOH) have previously been shown to reduce the number of neoplastic lesions and the growth rate of polyps in the colon of azoxymethane (AOM) treated rats. Based on previous investigations, it appears that different mechanisms of actions are involved in the antineoplastic effect of FaOH and FaDOH. One mechanism of action may be related to the antibacterial effect of FaOH and FaDOH and thus their effect on the gut microbiota. This study aimed to determine the effect of FaOH and FaDOH on gut microbiota composition of AOM treated rats. Results: Azoxymethane treated rats were fed either a standard rat diet or a rat diet supplemented with FaOH and FaDOH. The gut microbiota of AOM-induced rats was determined by 16S rRNA gene-amplicon sequencing. Analysis of fecal cecum samples demonstrated a significant gut microbiota change in rats receiving standard rat diet supplemented with FaOH and FaDOH compared with the control group that only received the rat diet. Comparison of the gut microbiota of rats who developed large neoplasms in the colon with rats without large neoplasms showed that the gut microbiota was significantly different in rats who developed large colon neoplasms compared to rats with no macroscopic colon neoplasms.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje