Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges
| Autor: | Stylianou, E, Paul, MJ, Reljic, R, McShane, H |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tuberculosis aerosol mucosal Immunology challenges Review Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Causative organism Drug Development Drug Discovery medicine Administration Mucosal Humans 030212 general & internal medicine Tuberculosis Vaccines Intensive care medicine Immune mechanisms Pharmacology biology business.industry vaccination biology.organism_classification medicine.disease 3. Good health Vaccination 030104 developmental biology Molecular Medicine delivery business Tuberculosis vaccines |
| Zdroj: | Expert Review of Vaccines |
| ISSN: | 1744-8395 1476-0584 |
| Popis: | Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could be achieved. The route of entry of Mycobacterium tuberculosis, the causative organism, is via inhalation making TB primarily a respiratory disease. There is therefore good reason to hypothesize that a mucosally delivered vaccine against TB could be more effective than one delivered via the systemic route. Areas covered: This review summarizes the progress that has been made in the area of TB mucosal vaccines in the last few years. It highlights some of the strengths and shortcomings of the published evidence and aims to discuss immunological and practical considerations in the development of mucosal vaccines. Expert opinion: There is a growing body of evidence that the mucosal approach to vaccination against TB is feasible and should be pursued. However, further key studies are necessary to both improve our understanding of the protective immune mechanisms operating in the mucosa and the technical aspects of aerosolized delivery, before such a vaccine could become a feasible, deployable strategy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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