Evaluating HIV Viral Rebound Among Persons on Suppressive Antiretroviral Treatment in the Era of 'Undetectable Equals Untransmittable (U = U)'
| Autor: | Joseph M Garland, Sugi Min, Fizza S. Gillani, Su Aung, Curt G. Beckwith |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Viral rebound
medicine.medical_specialty business.industry viruses Human immunodeficiency virus (HIV) rebound Retrospective cohort study undetectable suppression medicine.disease_cause Logistic regression Major Articles Men who have sex with men monitoring AcademicSubjects/MED00290 Infectious Diseases prevention Oncology Internal medicine Cohort Medicine Viral suppression business Viral load |
| Zdroj: | Open Forum Infectious Diseases |
| ISSN: | 2328-8957 |
| DOI: | 10.1093/ofid/ofaa529 |
| Popis: | Background Studies have demonstrated that persons with HIV (PWH) maintaining viral suppression do not transmit HIV to HIV-negative partners through condomless sex, leading to the “Undetectable = Untransmittable (U = U)” prevention campaign. However, few studies have examined the durability of suppression in the era of U = U. Methods This retrospective cohort study was conducted in Providence, Rhode Island. PWH aged ≥18 years with documented viral suppression (defined as at least 1 viral load [VL] Results A total of 1242 patients with viral suppression were included in the baseline cohort. In each follow-up year, 85%–90% maintained viral suppression, 2%–5% experienced viral rebound, and 8%–10% had a gap in VL monitoring. Among those with viral rebound, approximately one-half were suppressed again within 6 months. In the logistic regression models, retention in care was significantly associated with viral suppression, while younger age, black race, high school or equivalent education, non–men who have sex with men, and history of incarceration were significantly associated with viral rebound. Conclusions In the U = U era, most patients with viral suppression who are retained in care are likely to maintain viral suppression over time. Some patients require additional support for regular VL monitoring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|