Regulation of ovarian function: the role of anti-Müllerian hormone
| Autor: | Alexandra L. L. Durlinger, Jenny A. Visser, Axel P. N. Themmen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Anti-Mullerian Hormone
Male endocrine system Embryology medicine.medical_specialty Receptors Peptide Mullerian Ducts Granulosa cell Gene Expression Ovary Mice Endocrinology Ovarian Follicle Internal medicine medicine Biomarkers Tumor Animals Humans Glycoproteins Granulosa Cell Tumor Mice Knockout Ovarian Neoplasms Granulosa Cells biology Obstetrics and Gynecology Anti-Müllerian hormone Cell Biology Transforming growth factor beta Growth Inhibitors Rats Testicular Hormones medicine.anatomical_structure Reproductive Medicine Depression Chemical biology.protein Female Male sex differentiation Folliculogenesis Follicle Stimulating Hormone Receptors Transforming Growth Factor beta hormones hormone substitutes and hormone antagonists Biomarkers Transforming growth factor Signal Transduction |
| Zdroj: | Reproduction (Cambridge, England). 124(5) |
| ISSN: | 1470-1626 |
| Popis: | Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is a member of the transforming growth factor beta superfamily of growth and differentiation factors. In contrast to other members of the family, which exert a broad range of functions in multiple tissues, the principal function of AMH is to induce regression of the Mullerian ducts during male sex differentiation. However, the patterns of expression of AMH and its type II receptor in the postnatal ovary indicate that AMH may play an important role in ovarian folliculogenesis. This review describes several in vivo and in vitro studies showing that AMH participates in two critical selection points of follicle development: it inhibits the recruitment of primordial follicles into the pool of growing follicles and also decreases the responsiveness of growing follicles to FSH. |
| Databáze: | OpenAIRE |
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