T follicular helper cells and antibody response to Hepatitis B virus vaccine in HIV-1 infected children receiving ART
| Autor: | Mahlet Lemma, Temesgen E. Andargie, Desalegn Yibeltal, Rawleigh Howe, Yonas Bekele, Abraham Aseffa, Eyasu Mekonnen, Francesca Chiodi, Meseret Gebre, Kidist Bobosha, Anna Nilsson, Abiy Habtewold |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Hepatitis B virus Anti-HIV Agents Science HIV Infections Drug Administration Schedule Article 03 medical and health sciences Antigen Follicular phase Humans Medicine Hepatitis B Vaccines Lymphocyte Count Prospective Studies Hepatitis B Antibodies CXCL13 Child Prospective cohort study Multidisciplinary business.industry virus diseases Cancer T-Lymphocytes Helper-Inducer Hepatitis B medicine.disease Virology Vaccination Titer 030104 developmental biology Antibody response Case-Control Studies Child Preschool Immunology HIV-1 Cytokines Female business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-09165-6 |
| Popis: | HBV vaccine has 95% efficacy in children to prevent HBV infection and related cancer. We conducted a prospective study in HIV-1 infected children receiving ART (n = 49) and controls (n = 63) to assess humoral and cellular responses to HBV vaccine provided with three doses under an accelerated schedule of 4 weeks apart. At 1 month post-vaccination all children, except 4 HIV-1 infected, displayed protective antibody (ab) titers to HBV vaccine; ab titers were lower in infected children (P |
| Databáze: | OpenAIRE |
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