Home sampling and pooling of vaginal samples are effective tools for genetic screening of Chlamydia trachomatis among high school female students in Lithuania

Autor:	Zemyna Milasauskiene, V Juseviciute, Magnus Unemo, Vesta Kucinskiene, Skaidra Valiukeviciene, Marius Domeika
Rok vydání:	2008
Předmět:	Adult Microbiology (medical) Sexually transmitted disease Pathology medicine.medical_specialty Adolescent Cost-Benefit Analysis Sexual Behavior Vaginal Diseases Population Pooling Chlamydia trachomatis Sample (statistics) medicine.disease_cause Specimen Handling Prevalence medicine Humans Mass Screening Sampling (medicine) Students education Oligonucleotide Array Sequence Analysis Vaginal Smears Response rate (survey) education.field_of_study General Immunology and Microbiology business.industry Lithuania General Medicine Chlamydia Infections Self Care Infectious Diseases medicine.anatomical_structure Vagina Female business Demography
Zdroj:	Scandinavian Journal of Infectious Diseases. 40:88-93
ISSN:	1651-1980 0036-5548
DOI:	10.1080/00365540701587002
Popis:	The aims were 1) to estimate the prevalence of C. trachomatis infection among sexually active female students in Kaunas, Lithuania; 2) to investigate the usefulness of personal invitation, self-sampling, and pooling of samples for screening; and 3) to evaluate the costs of the approaches used. A cross-sectional study inviting 795 female students (18-31 y of age) from 7 high schools and 1 college in Kaunas was performed. The response rate was 67% (533/795). Self-obtained vaginal samples were analysed, individually and pooled (n = 3), using Digene Hybrid Capture II CT/NG Test. The overall prevalence of C. trachomatis infection was 5.6%. Among the sexually active female students 20-24 y of age (n = 424), the prevalence was 7.1%; however, the prevalence varied from 0% to 14.2% at the different schools. For estimation of the population prevalence based solely on identification of C. trachomatis positive pools, the pooling strategy reduced the costs by 85%. For estimation of population prevalence and for diagnosis of each individual sample, pooling reduced the costs by 70%. Targeted screening, using pooling to reduce the expenses, mainly of 3rd and 4th y Lithuanian female students could be recommended. By extended personal contact and internet-based communication, increased participation rates may be attained.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a11a2158988f394effbbd9d645f124 https://doi.org/10.1080/00365540701587002 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.