Genomic Evidence for Local Adaptation of Hunter-Gatherers to the African Rainforest
| Autor: | Alain Froment, Sylvie Le Bomin, Katherine J. Siddle, Paul Verdu, Etienne Patin, Jean-Marie Hombert, Patrick Mouguiama-Daouda, Martin Sikora, Carlos Bustamante, Luis B. Barreiro, George H. Perry, Marie Lopez, Christine Harmant, Jeremy Choin, Lluis Quintana-Murci, Martin Silvert, Helio A. Costa |
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| Přispěvatelé: | Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université de Copenhague, Stanford University School of Medicine [CA, USA], Laboratoire Langue, Culture et Cognition [Libreville, Gabon] (LCC), Université Omar Bongo [Libreville, Gabon], Dynamique Du Langage (DDL), Université Lumière - Lyon 2 (UL2)-Centre National de la Recherche Scientifique (CNRS), Eco-Anthropologie et Ethnobiologie (EAE), Muséum national d'Histoire naturelle (MNHN)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Pennsylvania State University (Penn State), Penn State System, University of Illinois [Chicago] (UIC), University of Illinois System, This work was supported by the Institut Pasteur, the Centre National de la Recherche Scientifique, the 'Histoire du Génome des Populations Humaines Gabonaises' project (Institut Pasteur/Republic of Gabon), and an Agence Nationale de la Recherche grant 'AGRHUM' (ANR-14-CE02-0003-01) to L.Q.-M. M.L. was supported by the Fondation pour la Recherche Médicale (FDT20170436932), and J.C. by the INCEPTION program and the 'Ecole Doctorale FIRE - Programme Bettencourt.', ANR-14-CE02-0003,AGRHUM,Etude de l'adaptation génétique aux changements environnementaux rapides : l'agriculture et le modèle humain(2014), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), University of Copenhagen = Københavns Universitet (UCPH), Patrimoines locaux, Environnement et Globalisation (PALOC), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Gene Flow Multifactorial Inheritance [SDV]Life Sciences [q-bio] Population Adaptation Biological Rainforest Biology Regulatory Sequences Nucleic Acid hunter-gatherers General Biochemistry Genetics and Molecular Biology Life history theory polygenic adaptation 03 medical and health sciences 0302 clinical medicine genetic adaptation Pleiotropy positive selection Humans Uganda Cameroon Gabon education Life Style Local adaptation 2. Zero hunger education.field_of_study Natural selection Farmers [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] Genome Human natural selection 15. Life on land immunity Repressor Proteins 030104 developmental biology Evolutionary biology Africa admixture Adaptation General Agricultural and Biological Sciences Selective sweep rainforest 030217 neurology & neurosurgery height |
| Zdroj: | Current Biology-CB Current Biology-CB, Elsevier, 2019, ⟨10.1016/j.cub.2019.07.013⟩ Current Biology-CB, 2019, 29 (17), pp.2926-2935.e4. ⟨10.1016/j.cub.2019.07.013⟩ |
| ISSN: | 0960-9822 1879-0445 |
| DOI: | 10.1016/j.cub.2019.07.013⟩ |
| Popis: | International audience; African rainforests support exceptionally high biodiversity and host the world's largest number of active hunter-gatherers [1-3]. The genetic history of African rainforest hunter-gatherers and neighboring farmers is characterized by an ancient divergence more than 100,000 years ago, together with recent population collapses and expansions, respectively [4-12]. While the demographic past of rainforest hunter-gatherers has been deeply characterized, important aspects of their history of genetic adaptation remain unclear. Here, we investigated how these groups have adapted-through classic selective sweeps, polygenic adaptation, and selection since admixture-to the challenging rainforest environments. To do so, we analyzed a combined dataset of 566 high-coverage exomes, including 266 newly generated exomes, from 14 populations of rainforest hunter-gatherers and farmers, together with 40 newly generated, low-coverage genomes. We find evidence for a strong, shared selective sweep among all hunter-gatherer groups in the regulatory region of TRPS1-primarily involved in morphological traits. We detect strong signals of polygenic adaptation for height and life history traits such as reproductive age; however, the latter appear to result from pervasive pleiotropy of height-associated genes. Furthermore, polygenic adaptation signals for functions related to responses of mast cells to allergens and microbes, the IL-2 signaling pathway, and host interactions with viruses support a history of pathogen-driven selection in the rainforest. Finally, we find that genes involved in heart and bone development and immune responses are enriched in both selection signals and local hunter-gatherer ancestry in admixed populations, suggesting that selection has maintained adaptive variation in the face of recent gene flow from farmers. |
| Databáze: | OpenAIRE |
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