Possible role of hyposensitivity of C-fiber afferents at the proximal urethra in the development of urge urinary incontinence in patients with detrusor overactivity
| Autor: | Sei Naito, Osamu Ichiyanagi, Manabu Ishigooka, Akira Nagaoka, Norihiko Tsuchiya, Masaaki Tsukigi, Mayu Yagi, Tomoyuki Kato |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Urge urinary incontinence Urology 030232 urology & nephrology Stimulation 03 medical and health sciences Young Adult 0302 clinical medicine Urethra Filling cystometry Lower urinary tract symptoms Sensation medicine PROXIMAL URETHRA Humans In patient Aged Retrospective Studies Aged 80 and over Nerve Fibers Unmyelinated 030219 obstetrics & reproductive medicine business.industry Urinary Bladder Overactive Medical record Urinary Incontinence Urge Middle Aged medicine.disease Urodynamics Neurology Female business |
| Zdroj: | Lower urinary tract symptoms. 11(2) |
| ISSN: | 1757-5672 |
| Popis: | Objective The aim of the present study was to investigate associations between urethral sensation and urge urinary incontinence (UUI) in patients with and without detrusor overactivity (DO). Methods The medical records of 80 consecutive patients who underwent filling cystometry and urethral current perception threshold (CPT) tests were examined retrospectively. Following the exclusion of 4 patients not eligible for analysis, patients were classified into neurogenic DO, idiopathic DO, or DO-negative groups based on neurological and cystometric findings (n = 30, 12, and 34, respectively). Eleven DO-negative patients were defined as normal controls on cystometrograms (CMG) using the following exclusion criteria: bladder compliance 275 mL at first filling sensation, and comorbidities possibly affecting lower urinary tract function. Thus, 53 patients were finally included in the study. Proximal urethral CPT was evaluated with intraurethral square-wave stimulation at 3 Hz to activate C-fiber afferents. Results Median CPT was higher in neurogenic and idiopathic DO than in the normal CMG group (11.3 and 9.0 vs. 2.8 mA, respectively; P |
| Databáze: | OpenAIRE |
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