Intravenous paracetamol vs ibuprofen in renal colic: a randomised, double-blind, controlled clinical trial
| Autor: | Mustafa Serinken, Emrah Uyanik, E. Cenker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
vomiting double blind procedure drug safety Time Factors intervention study paracetamol medicine.medical_treatment clinical outcome Ibuprofen 02 engineering and technology fentanyl law.invention Fentanyl 020210 optoelectronics & photonics 0302 clinical medicine Randomized controlled trial law time factor nonsteroid antiinflammatory agent 0202 electrical engineering electronic engineering information engineering Prospective Studies Infusions Intravenous Saline comparative study Pain Measurement pain intensity adult Anti-Inflammatory Agents Non-Steroidal single drug dose analgesia intravenous drug administration female Treatment Outcome priority journal Anesthesia sodium chloride Vomiting medicine.symptom medicine.drug prospective study Visual analogue scale Urology comparative effectiveness parallel design Article vertigo 03 medical and health sciences Double-Blind Method medicine Humans Pain Management controlled study epigastric pain Renal colic intrafen human procedures Renal Colic Acetaminophen Acetaminophen/*therapeutic use Adult Anti-Inflammatory Agents Non-Steroidal/*therapeutic use Female Ibuprofen/*therapeutic use Pain Management/*methods Renal Colic/*drug therapy business.industry Emergency department organic chemicals cost effectiveness analysis visual analog scale 030208 emergency & critical care medicine major clinical study Treatment drug efficacy randomized controlled trial business kidney colic drug hypersensitivity |
| Popis: | Pain management is one of the essentials of emergency care. Renal colic secondary to urinary stone disease forms one of the most intense pain types. The present study aimed to compare the effect of intravenous ibuprofen to paracetamol in ceasing renal colic. This randomised double-blind study was composed of two intervention arms, intravenous paracetamol and intravenous ibuprofen. Study subjects were randomised to receive a single dose of either paracetamol, 1 g in 100 ml normal saline, or ibuprofen (800 mg in 100 ml normal saline) in a blinded fashion. Subjects reported pain intensity on a visual analogue scale with lines intersection multiples of ten just before the drug administration, 15 and 30 min after the study drug administration. Two hundred patients were randomised to either of two study arms: however, 97 patients in ibuprofen group and 99 patients in paracetamol groups were included into 30 minute analysis. Differences of pain improvements between two groups was 9.5 (5.4–13.7) at 15 min (p = 0.000) and 17.1 (11.9–22.5) at 30 min, those both favouring ibuprofen over paracetamol (p = 0.000). Although ten (10.1%) patients in paracetamol group needed rescue drug, there were only two (2%) patients in ibuprofen group (difference: 8%; 95% CI 0.7–16%, p = 0.02). Intravenous 800 mg ibuprofen is more effective than IV paracetamol in ceasing renal colic at 30 min. © 2017, Springer-Verlag GmbH Germany. |
| Databáze: | OpenAIRE |
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