BDNF and nicotine dependence: associations and potential mechanisms
Autor: | Sijie Tan, Daichao Wu, Ju Zou, Zeyi Huang, Meixiang Li, Xilin Qu |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
business.industry General Neuroscience Addiction media_common.quotation_subject Dopaminergic Tropomyosin receptor kinase B Nicotine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Nicotinic agonist Neurotrophic factors Synaptic plasticity Medicine business Neuroscience 030217 neurology & neurosurgery Acetylcholine receptor media_common medicine.drug |
Zdroj: | Reviews in the Neurosciences. 32:79-91 |
ISSN: | 2191-0200 0334-1763 |
Popis: | Smoking is the leading preventable cause of death worldwide and tobacco addiction has become a serious public health problem. Nicotine is the main addictive component of tobacco, and the majority of people that smoke regularly develop nicotine dependence. Nicotine addiction is deemed to be a chronic mental disorder. Although it is well known that nicotine binds to the nicotinic acetylcholine receptors (nAChRs) and activates the mesolimbic dopaminergic system (MDS) to generate the pleasant and rewarding effects, the molecular mechanisms of nicotine addiction are not fully understood. Brain-derived neurotrophic factor (BDNF) is the most prevalent growth factor in the brain, which regulates neuron survival, differentiation, and synaptic plasticity, mainly through binding to the high affinity receptor tyrosine kinase receptor B (TrkB). BDNF gene polymorphisms are associated with nicotine dependence and blood BDNF levels are altered in smokers. In this review, we discussed the effects of nicotine on BDNF expression in the brain and summarized the underlying signaling pathways, which further indicated BDNF as a key regulator in nicotine dependence. Further studies that aim to understand the neurobiological mechanism of BDNF in nicotine addcition would provide a valuable reference for quitting smoking and developing the treatment of other addictive substances. |
Databáze: | OpenAIRE |
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