Evaluation of seven X-chromosomal short tandem repeat loci located within the Xq26 region
| Autor: | Jeannett Edelmann, Frank Götz, Christa Augustin, Lydia Weißbach, Werner Brabetz, Frank Kloep, Sandra Hering, Reinhard Szibor, Heike Rodig |
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| Rok vydání: | 2010 |
| Předmět: |
Electrophoresis
Genetics Chromosomes Human X Polymorphism Genetic Sequence analysis Haplotype Locus (genetics) Sequence Analysis DNA Biology Polymerase Chain Reaction Pathology and Forensic Medicine law.invention Haplotypes STR analysis Tandem Repeat Sequences law Tandem Repeat Sequence Humans Microsatellite X chromosome Polymerase chain reaction DNA Primers |
| Zdroj: | Forensic Science International: Genetics. 4:194-199 |
| ISSN: | 1872-4973 |
| DOI: | 10.1016/j.fsigen.2009.08.010 |
| Popis: | In this study a set of 29 X-chromosomal short tandem repeats (STRs) located within the Xq26 region was evaluated. These STRs were found within the 133.14–133.45 Mb region around the HPRTB locus. Evaluation of the microsatellites was performed with regard to polymorphism, reliable amplification, and low stutter artefacts. DXS10101, DXS10102, and DXS10103 were identified as those X-STRs with highest diversity; i.e. PIC values of 0.7174–0.8933. The locus DXS10101 was the optimal candidate for the integration in the commercial available test system Mentype Argus X-8 PCR amplification kit. |
| Databáze: | OpenAIRE |
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