Stem cell therapies for autoimmune hepatitis
| Autor: | Anna Burdzinska, Gamal Shiha, Ayman A. Swelum, Ahmed Lotfy, Reham Soliman, Aya El-Gamal, Ayman A. Hassan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Medicine (General) Medicine (miscellaneous) Autoimmune hepatitis Review Stem cells QD415-436 Mesenchymal Stem Cell Transplantation Exosomes Biochemistry Genetics and Molecular Biology (miscellaneous) Biochemistry Umbilical Cord 03 medical and health sciences 0302 clinical medicine Immune system R5-920 medicine Humans Mesenchymal stem cell business.industry Mesenchymal stromal cell Mesenchymal Stem Cells Cell Biology medicine.disease Microvesicles Haematopoiesis Hepatitis Autoimmune 030104 developmental biology medicine.anatomical_structure Adipose Tissue 030220 oncology & carcinogenesis Immunology Molecular Medicine Bone marrow Stem cell business Hematopoietic stem cells Adult stem cell |
| Zdroj: | Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021) Stem Cell Research & Therapy |
| ISSN: | 1757-6512 |
| Popis: | Autoimmune hepatitis is a chronic inflammatory hepatic disorder which may cause liver fibrosis. Appropriate treatment of autoimmune hepatitis is therefore important. Adult stem cells have been investigated as therapies for a variety of disorders in latest years. Hematopoietic stem cells (HSCs) were the first known adult stem cells (ASCs) and can give rise to all of the cell types in the blood and immune system. Originally, HSC transplantation was served as a therapy for hematological malignancies, but more recently researchers have found the treatment to have positive effects in autoimmune diseases such as multiple sclerosis. Mesenchymal stem cells (MSCs) are ASCs which can be extracted from different tissues, such as bone marrow, adipose tissue, umbilical cord, and dental pulp. MSCs interact with several immune response pathways either by direct cell-to-cell interactions or by the secretion of soluble factors. These characteristics make MSCs potentially valuable as a therapy for autoimmune diseases. Both ASC and ASC-derived exosomes have been investigated as a therapy for autoimmune hepatitis. This review aims to summarize studies focused on the effects of ASCs and their products on autoimmune hepatitis. |
| Databáze: | OpenAIRE |
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