Th17 and regulatory T cells contribute to the in situ immune response in skin lesions of Jorge Lobo's disease
| Autor: | Juarez Antônio Simões Quaresma, Carla Pagliari, Tania Cristina Barboza, Arival Cardoso de Brito, Maria Irma Seixas Duarte, Clivia Maria Moraes de Oliveira, Luciane Kanashiro-Galo, Deborah Aben Athar Unger, Mirian Nacagami Sotto, Marília Brasil Xavier |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Biopsy chemical and pharmacologic phenomena Biology T-Lymphocytes Regulatory Immune system medicine Humans IL-2 receptor Lobomycosis Skin Epidermis (botany) Interleukins Interleukin-2 Receptor alpha Subunit Interleukin FOXP3 hemic and immune systems Forkhead Transcription Factors General Medicine Middle Aged medicine.disease Immunohistochemistry Infectious Diseases Cytokine Granuloma Immunology Interleukin 12 Th17 Cells Female |
| Zdroj: | Medical mycology. 54(1) |
| ISSN: | 1460-2709 |
| Popis: | Jorge Lobo's disease (JLD) is a chronic granulomatous mycosis described in various Latin American countries. The main objective of the present study was to investigate the possible role of Th17 and Foxp3+ Treg cells in the pathogenesis of Jorge Lobo's disease. Human skin biopsies were submitted to an immunohistochemistry protocol to detect Foxp3, interleukin (IL)-1beta, CD25, IL-6, IL-17, and IL-23. The epidermis presented acanthosis, hyperkeratosis, and frequent presence of fungi. The dermis presented inflammatory infiltrate comprising macrophages, lymphocytes, epithelioid and multinucleated cells, and an intense number of fungi. Foxp3+ Treg cells and IL-17+ cells were visualized in lymphocytes in the inflammatory infiltrate. IL-1, IL-2R (CD25), IL-6, and IL-23 were visualized in the dermis, intermingled with fungal cells, permeating or participating of the granuloma. Following IL-17, the most prominent cytokine was IL-6. IL-23 and cells expressing CD25 were present in fewer number. The comparative analysis between IL-17 and Foxp3 demonstrated a statistically significant increased number of IL-17+ cells. Th17 cells play a role in the immune response of JLD. IL-1beta and IL-6 added to the previously described increased number of TGF-beta would stimulate such pattern of response. Th17 cells could be present as an effort to modulate the local immune response; however, high levels of a Th17 profile could overcome the role of Treg cells. The unbalance between Treg/Th17 cells seems to corroborate with the less effective immune response against the fungus. |
| Databáze: | OpenAIRE |
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