In vitro fertilization with single-Nucleotide polymorphism microarray-based preimplantation genetic testing for aneuploidy significantly improves clinical outcomes in infertile women with recurrent pregnancy loss: A randomized controlled trial
| Autor: | Yueping Zhang, Xiandong Peng, Jiangfeng Ye, Lu Li, Caixia Lei, Shuo Zhang, Guowu Chen, Jing Fu, Xiaoxi Sun, Yi-Lun Sui |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty medicine.medical_treatment Aneuploidy Subgroup analysis lcsh:Diseases of the endocrine glands. Clinical endocrinology Miscarriage law.invention assisted reproductive treatment Randomized controlled trial law medicine Pregnancy In vitro fertilisation recurrent pregnancy loss lcsh:RC648-665 business.industry Obstetrics Obstetrics and Gynecology medicine.disease Embryo transfer clinical outcomes Reproductive Medicine preimplantation genetic testing for aneuploidy Live birth business lcsh:RC581-607 |
| Zdroj: | Reproductive and Developmental Medicine, Vol 4, Iss 1, Pp 32-41 (2020) |
| ISSN: | 2589-8728 2096-2924 |
| Popis: | Objective: To evaluate the effect of preimplantation genetic testing for aneuploidy (PGT-A) in infertile patients with recurrent pregnancy loss (RPL). Methods: A prospective randomized clinical trial was performed in a university-affiliated fertility center in Shanghai, China. Patients in the PGT-A group underwent blastocyst biopsy followed by single-nucleotide polymorphism microarray-based PGT-A and single euploid blastocyst transfer, whereas patients in the control group underwent routinein vitro fertilization/ICSI procedures and frozen embryo transfer of 1–2 embryos selected according to morphological standards. Results: Two hundred and seven infertile patients with RPL were included in this study and randomly assigned to either the control or the PGT-A group. Baseline variables and cycle characteristics were comparable between the two groups. The results showed that PGT-A significantly improved the ongoing pregnancy rate (55.34% vs. 29.81%) as well as the live birth rate (48.54% vs. 27.88%) and significantly reduced the miscarriage rate (0.00% vs. 14.42%) on a per-patient analysis. A significant increase in cumulative ongoing pregnancy rates over time was observed in the PGT-A group. Subgroup analysis showed that the significant benefit diminished for patients who attempted ≥2 PGT-A cycles. Conclusions: PGT-A significantly improved the ongoing pregnancy and live birth rate, while reduced miscarriage rate in infertile RPL patients. However, the significance diminished in patients attempting ≥2 cycles; thus, further studies are warranted to explore the most cost-effective number of attempts in these patients to avoid overuse. |
| Databáze: | OpenAIRE |
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