Comparison of HbA1 and fructosamine in diagnosis of glucose-tolerance abnormalities
| Autor: | Eveline Eschwège, J. Peynet, Valérie Godard, F Rousselet, Marie-Aline Charles, F Paolaggi, José Timsit, Jean Lubetzki, Pierre Jean Guillausseau, Philippe Chanson |
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| Rok vydání: | 1990 |
| Předmět: |
Blood Glucose
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism education Asymptomatic World health chemistry.chemical_compound Internal medicine Diabetes mellitus Internal Medicine Diabetes Mellitus Medicine Humans Screening tool Oral glucose tolerance Advanced and Specialized Nursing Glycated Hemoglobin business.industry Hexosamines Glucose Tolerance Test medicine.disease Fructosamine Endocrinology Cross-Sectional Studies chemistry Hemoglobin medicine.symptom business |
| Zdroj: | Diabetes care. 13(8) |
| ISSN: | 0149-5992 |
| Popis: | Total glycosylated hemoglobin (HbA1) and fructosamine were evaluated as screening tools for detection of glucose-tolerance abnormalities in 144 asymptomatic subjects undergoing a 75-g oral glucose tolerance test. Subjects were classified according to World Health Organization criteria as having normal (n = 78), impaired (n = 40), or diabetic (n = 26) glucose tolerance. We found good specificity for HbA1 and fructosamine (100 and 97%, respectively) but low sensitivity (15 and 19%, respectively). At the intersection of the curves of sensitivity and specificity drawn from various thresholds of normality, both sensitivity and specificity were 75% for HbA1 and 55% for fructosamine. Thus, neither HbA1 nor fructosamine seems to be suitable for the diagnosis of mild abnormalities in glucose tolerance. |
| Databáze: | OpenAIRE |
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