Smads and chromatin modulation
| Autor: | Kristin Verschueren, Danny Huylebroeck, Griet Verstappen, Leonardus Van Grunsven |
|---|---|
| Přispěvatelé: | Cell Biology and Histology |
| Předmět: |
Endocrinology
Diabetes and Metabolism Immunology Smad Proteins SMAD DNA-binding protein General Biochemistry Genetics and Molecular Biology Chromatin remodeling Histones Transforming Growth Factor beta Immunology and Allergy Animals Humans smads Transcription factor biology Transforming growth factor beta Chromatin Assembly and Disassembly Chromatin DNA-Binding Proteins biology.protein Cancer research Trans-Activators Transforming growth factor Bivalent chromatin Signal Transduction |
| Zdroj: | Vrije Universiteit Brussel |
| Popis: | Smad proteins are critical intracellular effector proteins and regulators of transforming growth factor type beta (TGFbeta) modulated gene transcription. They directly convey signals that initiate at ligand-bound receptor complexes and end in the nucleus with changes in programs of gene expression. Activated Smad proteins seem to recruit chromatin modifying proteins to target genes besides cooperating with DNA-bound transcription factors. We survey here the current and still emerging knowledge on Smad-binding factors, and their different mechanisms of chromatin modification in particular, in Smad-dependent TGFbeta signaling. |
| Databáze: | OpenAIRE |
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