Suxamethonium – Electromyographic Studies in Children
| Autor: | T. C. K. Brown, B. Bell, O. A. Meretoja, D. Clare |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Aging
Time Factors Adolescent Electrodiagnosis Neuromuscular Junction Succinylcholine Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Age groups Confidence Intervals medicine Humans In patient 030212 general & internal medicine Child Analysis of Variance Dose-Response Relationship Drug medicine.diagnostic_test Electromyography business.industry Infant 030208 emergency & critical care medicine Anesthesiology and Pain Medicine Child Preschool Anesthesia Anesthesia Recovery Period Regression Analysis business Muscle Contraction |
| Zdroj: | Anaesthesia and Intensive Care. 18:473-476 |
| ISSN: | 1448-0271 0310-057X |
| DOI: | 10.1177/0310057x9001800409 |
| Popis: | Suxamethonium was administered to 225 children aged from one to sixteen years, in doses varying from 0.1 to 0.5 mg/kg. Dose responses were determined. ED95 was 445 μg/kg in one to four year olds, 454 μg/kg in the five to ten years group and 270 μg/kg in eleven to fifteen year olds (P < 0.05). There is a wider variability in patient responses to 0.1 and 0.2 mg/kg than to the higher doses. Sixty-two children in the three age groups were given suxamethonium 1 mg/kg. The time from injection to maximum block and to 50% recovery increased with increasing age (P< 0.05). |
| Databáze: | OpenAIRE |
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