Analysis of a single nucleotide polymorphism in codon 388 of the FGFR4 gene in malignant gliomas
| Autor: | Sabine Diete, Siegfried Kropf, Sabine Krüger, Christian Mawrin, Knut Dietzmann, Elmar Kirches, Bernhard Bogerts, Falk R. Wiedemann, Raimund Firsching, Christian K. Vorwerk, Thomas Schneider |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Single-nucleotide polymorphism Biology Polymerase Chain Reaction Polymorphism Single Nucleotide FGFR4 Gene Cell Line Tumor medicine Humans Receptor Fibroblast Growth Factor Type 4 U87 Codon neoplasms DNA Primers Base Sequence Brain Neoplasms Fibroblast growth factor receptor 4 Glioma medicine.disease Immunohistochemistry nervous system diseases Oncology Cancer research Polymorphism Restriction Fragment Length Anaplastic astrocytoma Glioblastoma |
| Zdroj: | Cancer letters. 239(2) |
| ISSN: | 0304-3835 |
| Popis: | The FGFR4 codon 388 polymorphism (Arg(388), Arg/Gly(388) or Gly(388)) was determined in glioblastoma multiforme (GBM), anaplastic astrocytomas (AA), diffuse astrocytomas (DA), and control muscles. Arg(388) was rare in AA, GBM, muscles, and was absent in DA. The Arg/Gly(388) and the Gly(388) frequency was equal among GBM and controls. FGFR4 expression was not related to codon 388 in GBM, and no survival differences between Arg/Gly(388) and Gly(388) tumors were found. U87 cells (Arg/Gly(388)) did not show higher invasion than U138 cells (Gly(388)). This suggests that the FGFR4 codon 388 status does not play a major role in malignant gliomas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect