Cholangiohepatitis in Dairy Cattle: 13 Cases
| Autor: | Diego E Gomez, Elizabeth Doré, H. Pierre, André Desrochers, Gilles Fecteau, David Francoz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty 040301 veterinary sciences Cholangitis Biopsy Hyperglobulinemia Cattle Diseases Standard Article 030230 surgery Vulva 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Hepatic medicine Animals Hypoalbuminemia Leukocytosis Udder Dairy cattle Retrospective Studies Ultrasonography FOOD AND FIBER ANIMAL Cholestasis General Veterinary Hepatology business.industry Antemortem Diagnosis Icterus 04 agricultural and veterinary sciences medicine.disease Neutrophilia Standard Articles medicine.anatomical_structure Liver Cattle Female Bile Ducts medicine.symptom business |
| Zdroj: | Journal of Veterinary Internal Medicine |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | Background The signalment, clinicopathologic, bacteriological, histopathological, ultrasonographic characteristics, and the treatment and outcomes of adult cattle with cholangiohepatitis are poorly defined. Animals Thirteen Holstein cows with cholangiohepatitis. Methods Retrospective study of medical records of cattle admitted to the CHUV and the AVC between 1992 and 2012 and 2000 and 2012, respectively, for cattle older than 3 months of age with a histopathological diagnosis of cholangiohepatitis. Cholangiohepatitis was defined as the presence of portal inflammation surrounding or infiltrating bile ducts, with or without epithelial damage, and extending into the adjacent lobules. Results At the time of diagnosis of cholangiohepatitis, cows had decreased appetite (n = 7) or were anorectic (n = 6), had fever (n = 5), and had tachycardia (n = 8). Icterus was detected in 5 cows. Yellow discoloration was identified on the skin of the udder (n = 3), conjunctiva (n = 2), and vulva (n = 1). There was leukocytosis (n = 6), neutrophilia (n = 9), and hyperfibrinogenemia (n = 8). Alteration in the serum biochemistry profile included hyperglobulinemia (n = 8), hypoalbuminemia (n = 10), increased activity of GGT (n = 12), AST (n = 8), and ALP (n = 10), and hyperbilirubinemia (n = 10). Histopathological diagnosis included mild, subacute, nonsuppurative cholangiohepatitis (n = 4), mild suppurative cholangiohepatitis (n = 4), mild mixed (neutrophilic and lymphocytic) cholangiohepatitis (n = 3), and moderate, chronic, nonsuppurative cholangiohepatitis (n = 1). Six cows were discharged from the hospital, and 7 were euthanized. Conclusions and Clinical Importance Cholangiohepatitis is a rare condition in adult cattle. Antemortem diagnosis can be challenging because clinical signs are unspecific. |
| Databáze: | OpenAIRE |
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