Proteomic Analysis of Rat Kidney Cortex Following Treatment with Gentamicin
| Autor: | Patrick Camilleri, Peter G. Lord, Joanne Charlwood, Peter J. Bugelski, N. King, J. Mark Skehel, Uzma Atif |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Kidney Cortex Proteome Pharmacology Biology Models Biological Biochemistry Mass Spectrometry Nephrotoxicity Rats Sprague-Dawley chemistry.chemical_compound Cortex (anatomy) medicine Animals Electrophoresis Gel Two-Dimensional Databases Protein Fatty acid synthesis Kidney Gene Expression Profiling General Chemistry Anti-Bacterial Agents Mitochondria Rats Citric acid cycle medicine.anatomical_structure chemistry Gluconeogenesis Gentamicin Gentamicins medicine.drug |
| Zdroj: | Journal of Proteome Research. 1:73-82 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/pr0100063 |
| Popis: | The regionally specific structure and function of the kidney renders it susceptible to toxic exposure. To characterize these changes at the proteome level, we have investigated the effects on protein expression following treatment with gentamicin.The more than 20 proteins identified were involved in the citric acid cycle, gluconeogenesis, fatty acid synthesis, and transport or cellular stress responses. These results strongly support the notion that energy production is impaired and mitochondrial dysfunction is involved in gentamicin-induced nephrotoxicity. Keywords: gentamicin • nephrotoxicity • kidney cortex |
| Databáze: | OpenAIRE |
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