Deficiency of a neuronal growth-sustaining factor in fibroblasts of patients with Alzheimer's disease
| Autor: | Audrius V. Plioplys |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Cell Survival medicine.medical_treatment Central nervous system Central nervous system disease Mice Tissue culture Degenerative disease Alzheimer Disease Internal medicine medicine Animals Humans Nerve Growth Factors Aged Neurons Growth factor Fibroblasts medicine.disease Pathophysiology Endocrinology medicine.anatomical_structure Neurology Culture Media Conditioned Cholinergic Female Neurology (clinical) Alzheimer's disease Psychology |
| Zdroj: | Journal of the Neurological Sciences. 133:24-30 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/0022-510x(95)00171-w |
| Popis: | A previous report has shown a deficiency of a cholinergic differentiating factor in spent culture media in which Alzheimer's disease (AD) patient fibroblasts were grown (Kessler, 1987). We used a similar approach to investigate whether AD fibroblast-conditioned medium demonstrated central nervous system (CNS) neuronal growth sustaining properties. For these investigations we used cultured fetal murine telencephalic vesicle neurons. Control fibroblast-conditioned medium produced statistically significant neuronal survival as compared to AD fibroblast-conditioned medium or to nonconditioned medium. There was no statistically significant difference between AD fibroblast-conditioned medium and nonconditioned medium results. These results suggest that there may be a deficiency in AD of a CNS neuronal growth-sustaining factor. |
| Databáze: | OpenAIRE |
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