| Popis: |
The antidiarrhoeic activity of the methanolic leaf extract of Manniophyton africanum (MEMA) has been evaluated out in mice using different models (Castor oil-induced diarrhoea, effects on gastrointestinal motility, and castor oil-induced gastric enteropooling). MEMA (200,400 and 600 mg/kg, p.o.) inhibited at 5% significance level, the frequency of defecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, markedly inhibited the movement of charcoal meal plug through the gastrointestinal tract, in a dose dependent manner, comparable to diphenoxylate and atropine. It however had no effect in the intra luminal fluid content in the castor oil-induced gastric enteropooling. Diphenoxylate (5 mg/kg) and atropine (3 mg/kg) were used as the reference drugs. MEMA were also found to be possessing marginal (52-66%) free radical scavenging activities in vitro using the DPPH and FRAP models. The remarkable antidiarrhoeal property of MEMA in vivo gives credence to its use in the management of a wide range of diarrhoeal state. |
