Dog colour patterns explained by modular promoters of ancient canid origin
| Autor: | DoGA consortium, Bannasch, Danika L., Kaelin, Christopher B., Letko, Anna, Loechel, Robert, Hug, Petra, Jagannathan, Vidhya, Henkel, Jan, Roosje, Petra, Hytönen, Marjo K., Lohi, Hannes, Arumilli, Meharji, Minor, Katie M., Mickelson, James R., Drogemuller, Cord, Barsh, Gregory S., Leeb, Tosso, Iivanainen, Antti |
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| Přispěvatelé: | Medicum, Haartman Institute (-2014), Biosciences, Veterinary Biosciences, Helsinki One Health (HOH), Hannes Tapani Lohi / Principal Investigator, Veterinary Genetics, Department of Medical and Clinical Genetics, Antti Iivanainen / Principal Investigator, Veterinary Anatomy and Developmental Biology, Developmental interactions |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
BLACK-AND-TAN
Evolutionary biology 413 Veterinary science Domestication 0302 clinical medicine Hair cycle 2.2 Factors relating to the physical environment Aetiology 610 Medicine & health SADDLE TAN Phylogeny DoGA consortium 0303 health sciences Natural selection Ecology Phylogenetic tree 630 Agriculture Inheritance (genetic algorithm) ASSOCIATION ADMIXTURE White (mutation) 590 Animals (Zoology) EXPRESSION Coat Genotype Color PHENOTYPES Biology INHERITANCE Article 03 medical and health sciences Dogs Genetic Genetics Animals Selection Genetic Selection Ecology Evolution Behavior and Systematics Animal breeding 030304 developmental biology Wolves IDENTIFICATION MUTATIONS Haplotype PIGMENTATION 570 Life sciences biology 030217 neurology & neurosurgery |
| Zdroj: | Bannasch, Danika L.; Kaelin, Christopher B; Letko, Anna; Loechel, Robert; Hug, Petra; Jagannathan, Vidhya; Henkel, Jan; Roosje, Petra; Hytönen, Marjo K; Lohi, Hannes; Arumilli, Meharji; Minor, Katie M; Mickelson, James R; Drögemüller, Cord; Barsh, Gregory S; Leeb, Tosso (2021). Dog colour patterns explained by modular promoters of ancient canid origin. Nature ecology & evolution, 5(10), pp. 1415-1423. Nature Publishing Group 10.1038/s41559-021-01524-x Nature ecology & evolution, vol 5, iss 10 Nature Ecology & Evolution |
| Popis: | Distinctive colour patterns in dogs are an integral component of canine diversity. Colour pattern differences are thought to have arisen from mutation and artificial selection during and after domestication from wolves but important gaps remain in understanding how these patterns evolved and are genetically controlled. In other mammals, variation at the ASIP gene controls both the temporal and spatial distribution of yellow and black pigments. Here, we identify independent regulatory modules for ventral and hair cycle ASIP expression, and we characterize their action and evolutionary origin. Structural variants define multiple alleles for each regulatory module and are combined in different ways to explain five distinctive dog colour patterns. Phylogenetic analysis reveals that the haplotype combination for one of these patterns is shared with Arctic white wolves and that its hair cycle-specific module probably originated from an extinct canid that diverged from grey wolves more than 2 million years ago. Natural selection for a lighter coat during the Pleistocene provided the genetic framework for widespread colour variation in dogs and wolves. Dogs exhibit remarkable variation in colour patterns. Here, the authors identify structural variants of independent regulatory modules for ventral and hair cycle expression of the ASIP gene that explain five distinctive dog colour patterns and trace back the origin of one colour pattern to an extinct canid. |
| Databáze: | OpenAIRE |
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