Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats
| Autor: | Priscila Aiko Hiane, Camila Jordão Candido, Luciane Candeloro Portugal, Jeeser Alves de Almeida, Dhébora Albuquerque Dias, Rafael Del Ciampo Silva, Bruna de Barros Penteado, Gabriela Marcelino, Priscila Silva Figueiredo, Arnildo Pott, Rita de Cássia Avellaneda Guimarães, Jeandre Augusto dos Santos Jaques |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty food.ingredient Linseed Oil 030209 endocrinology & metabolism Inflammation fatty acids Article 03 medical and health sciences Eating Random Allocation 0302 clinical medicine food Linseed oil Non-alcoholic Fatty Liver Disease Internal medicine medicine steatosis Ingestion Animals Rats Wistar chemistry.chemical_classification Animal fat 030109 nutrition & dietetics Nutrition and Dietetics Interleukin-6 Interleukin alpha-Linolenic Acid medicine.disease Interleukin-10 Rats Endocrinology chemistry Adipose Tissue Gene Expression Regulation inflammation Steatosis medicine.symptom omega-3 Weight gain Nutritive Value Sesame Oil Food Science Polyunsaturated fatty acid |
| Zdroj: | Nutrients Volume 12 Issue 1 |
| ISSN: | 2072-6643 |
| Popis: | Consumption of omega-3 (n-3) polyunsaturated fatty acids (PUFA) is related to improvement in the inflammatory response associated with decreases in metabolic disorders of obesity, such as low-grade inflammation and hepatic steatosis. Linseed (Linum usitatissimum) oil is a primary source of n-3 fatty acids (FAs) of plant origin, particularly &alpha linolenic acid, and provides an alternative for the ingestion of n-3 PUFA by persons allergic to, or wishing to avoid, animal sources. In our study, we evaluated the effect of the consumption of different lipidic sources on metabolic and inflammatory parameters in Wistar rats. We split 56 male rats into four groups that were fed for 60 days with the following diets: sesame oil, (SO, Sesamum indicum), linseed oil (LO), SO + LO (SLO), and a control group (CG) fed with animal fat. Our results reveal that the use of LO or SLO produced improvements in the hepatic tissue, such as lower values of aspartate aminotransferase, liver weight, and hepatic steatosis. LO and SLO reduced the weight of visceral fats, weight gain, and mediated the inflammation through a decrease in interleukin (IL)-6 and increase in IL-10. Though we did not detect any significant differences in the intestine histology and the purinergic system enzymes, the consumption of &alpha linolenic acid appears to contribute to the inflammatory and hepatic modulation of animals compared with a diet rich in saturated FAs and or unbalanced in n-6/n-3 PUFAs, inferring possible use in treatment of metabolic disorders associated with obesity and cardiovascular diseases. |
| Databáze: | OpenAIRE |
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