Effects of scopolamine parenteral administration on the electroretinogram, visual evoked potentials, and quantitative electroencephalogram of healthy volunteers
| Autor: | Lino Maggi, Mauro Fioretto, Guido Rosadini, Walter G. Sannita |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Scopolamine Central nervous system Emmetropia Electroencephalography Audiology Placebo Retina Physiology (medical) Electroretinography medicine Humans Infusions Parenteral Latency (engineering) N75 Latency medicine.diagnostic_test Brain Quantitative electroencephalography Sensory Systems Ophthalmology medicine.anatomical_structure Anesthesia Evoked Potentials Visual sense organs Psychology |
| Zdroj: | Documenta Ophthalmologica. 67:379-388 |
| ISSN: | 1573-2622 0012-4486 |
| DOI: | 10.1007/bf00143956 |
| Popis: | Single intramuscular doses of scopolamine and matching placebo were administered to young, healthy, and emmetropic volunteers. Electroretinograms and visual evoked potentials (flash and pattern stimuli) were recorded prior to and 30, 90, and 120 min after administration. The effects of scopolamine at the central nervous system level were monitored also by quantitative electroencephalographic methods. Scopolamine reduced the peak-to-peak amplitude of the late components of the flash-evoked potential without affecting latencies. A decrease of the N75 latency and increment of N175 latency of pattern-evoked potentials were observed without any apparent modification of the amplitude values. These changes were not produced by administering topical cyclopentholate. Electroencephalographic effects were apparent with a longer delay after administration than were those on the visual evoked potentials. No significant modification was observed in the electroretinogram under these recording conditions. |
| Databáze: | OpenAIRE |
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