The effect of universal infant vaccination on the prevalence of hepatitis B immunity in adult solid organ transplant candidates

Autor: Geert Verleden, Robin Vos, Özgür M Koc, Jef Verbeek, Johan Van Cleemput, Astrid M. L. Oude Lashof, Geert Robaeys, Dirk Kuypers, Matthijs Kramer, Jan Van Keer, Frederik Nevens, Lieven Dupont
Přispěvatelé: Med Microbiol, Infect Dis & Infect Prev, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: DA Medische Microbiologie en Infectieziekten (5), RS: CAPHRI - R4 - Health Inequities and Societal Participation, MUMC+: MA Maag Darm Lever (9), Verbeek, Jef/0000-0002-1549-8003
Jazyk: angličtina
Rok vydání: 2021
Předmět:
SURFACE-ANTIGEN
medicine.medical_treatment
Abbreviations: BMI
body mass index
Liver transplantation
medicine.disease_cause
IMMUNOGENICITY
Organ transplantation
0302 clinical medicine
VIRUS INFECTION
Prevalence
030212 general & internal medicine
CLINICAL-PRACTICE GUIDELINE
Vaccination
SOT
solid organ transplant
Hepatitis B
LIVER-TRANSPLANTATION
IMMUNIZATION
Infectious Diseases
HBsAg
hepatitis B surface antigen
HLA
human leucocyte antigen
HCV
hepatitis C virus
030211 gastroenterology & hepatology
Original Article
CIRRHOTIC-PATIENTS
Viral hepatitis
CORE-POSITIVE DONORS
Adult
medicine.medical_specialty
Hepatitis B virus
03 medical and health sciences
Immunity
Virology
Internal medicine
medicine
Humans
Hepatitis B Vaccines
Hepatology
business.industry
solid organ transplant
Infant
Odds ratio
Original Articles
Organ Transplantation
medicine.disease
vaccination
EFFICACY
immunity
CI
confidence interval
OR
odds ratio
HBV
hepatitis B virus
VIRAL-HEPATITIS
business
Zdroj: Journal of Viral Hepatitis, 28(1), 105-111. Wiley
Journal of Viral Hepatitis
ISSN: 1365-2893
1352-0504
1997-2008
Popis: Background Hepatitis B virus (HBV) immunity is recommended to optimize outcomes after solid organ transplantation (SOT). This study assessed the prevalence and predictors of HBV immunity at the time patients were placed on transplant waiting list over a period from 1997 to 2019 in a low HBV endemic region. Methods Data were obtained from the University Hospitals Leuven transplant database. Minors and patients with past/current HBV infection were excluded. From 1986, Belgian patients are covered by the universal infant vaccination; therefore, birth cohort was stratified in those born >= 1986 vs The study population consisted of 3297 SOT candidates. HBV immunity rate was superior in renal transplant candidates (55.3%), and this number was 21.5%, 15.4% and 16.8% for liver, cardiac and pulmonary transplant candidates, respectively,P < .001. Among liver transplant candidates, HBV immunity rate was 14.8% in decompensated cirrhotic patients and 27.9% in those without advanced cirrhosis (P < .001). The overall immunity rate increased from 19.3% in period 1997-2008 to 32.8% in 2009-2019,P < .001. In multivariable analyses, younger age (odds ratio (OR) 95% confidence interval (CI): 0.97-0.98,P < .001) and birth cohort >= 1986 (OR 95% CI: 1.18-2.66,P = .006) were associated with increased HBV immunity. Conclusion An increase in HBV immunity was observed over a 20-year period related to the introduction of universal infant HBV vaccination. Nevertheless, this study highlights the low overall HBV immunity at the time of listing for organ transplantation and points out the need of an increased awareness and vaccination strategy at an early disease stage. This research is part of the Limburg Clinical Research Center (LCRC) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk, province of Limburg, Flemish government, Hasselt University, Jessa Hospital and Ziekenhuis Oost-Limburg. The authors specially thank Bruno Desschans and Albert Herelixka for the management of the transplant database. Koc, OM (corresponding author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. ozgur.koc@uhasselt.be
Databáze: OpenAIRE
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