Correlations between SUVmax and Expression of GLUT1 and Growth Factors Inducing Lymphangiogenesis
| Autor: | Xuan Gao, Yafang Zhang, Lijuan Yu, Mohan Tian |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Colorectal cancer Statistics as Topic Standardized uptake value Sensitivity and Specificity Gastroenterology Fluorodeoxyglucose F18 Internal medicine Image Interpretation Computer-Assisted medicine Carcinoma Lymphatic vessel Humans Radiology Nuclear Medicine and imaging Lymphangiogenesis Aged Glucose Transporter Type 1 business.industry Reproducibility of Results Middle Aged Image Enhancement medicine.disease medicine.anatomical_structure Lymphatic system Vascular endothelial growth factor C Lymphatic Metastasis Positron-Emission Tomography Subtraction Technique Intercellular Signaling Peptides and Proteins Immunohistochemistry Female Radiopharmaceuticals Colorectal Neoplasms Tomography X-Ray Computed business |
| Zdroj: | Academic Radiology. 19:420-426 |
| ISSN: | 1076-6332 |
| Popis: | Rationale and Objectives The purpose of this study was to assess the correlations between the maximum standardized uptake value (SUVmax) of colorectal carcinoma and hepatocyte growth factor (HGF), vascular endothelial growth factor C (VEGF-C), and their respective receptors using 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). Methods Fluorine-18-FDG PET/CT scans were performed on 33 patients with colorectal carcinoma before any treatment. The SUVmax of colorectal carcinoma and the clinicopathologic data associated with lymphatic metastases were analyzed. The expression of glucose transporter 1 (GLUT1), HGF, c-Met, VEGF-C, and vascular endothelial growth factor receptor 3 (VEGFR-3) in tumor tissues was analyzed using immunohistochemical methods. Lymphatic endothelial cells were marked with D2-40, and lymphatic vessel density (LVD) was recorded. The correlations were analyzed among the SUVmax of colorectal carcinoma, LVD, and the expression of GLUT1, HGF, c-Met, VEGF-C, and VEGFR-3 in tumor tissues. Results SUVmax and LVD in 15 patients with lymphatic metastases were 13.00 ± 4.51 and 6.25 ± 1.54, respectively, whereas in 18 patients with nonmetastatic nodes, SUVmax and LVD were 9.66 ± 4.82 and 4.54 ± 1.02, respectively. The differences of SUVmax and LVD between metastatic and nonmetastatic patients were statistically significant ( F = 4.153, P = .025, and F = 14.501, P = .001, respectively). There were no statistical differences of SUVmax and LVD in variably differentiated colorectal carcinoma ( F = 0.708, P = .502, and F = 0.311, P = .735, respectively). The expression rates of GLUT1 in neoplastic and normal tissue were 72.7% (24 of 33) and 21.2% (seven of 33), respectively ( P = .001). Moreover, the expression rates of GLUT1 in metastatic and nonmetastatic tissue were 93.33% (14 of 15) and 61.11% (11 of 18), respectively ( P = .038). LVD and the integrated optical density of GLUT1 were 5.31 ± 1.53 and 8.21 × 10 4 ± 4.30 × 10 4 , respectively, in tumor tissue, and there were linear correlations between SUVmax and LVD ( r = 0.373, P = .033) and between SUVmax and expression of GLUT1 ( r = 0.428, P = .013). The differences of SUVmax in HGF, c-Met, and VEGF-C groups with different expressions were statistically significant ( P = .007, P = .009, and P = .030, respectively). No correlation was found between the expression of VEGFR-3 and SUVmax. The expression of GLUT1 and HGF as well as of GLUT1 and VEGF-C was rank correlated ( r = 0.521, P = .002, and r = 0.505, P = .003, respectively). No rank correlations were found between the expression of GLUT1 and c-Met, GLUT1, and VEGFR-3. Conclusions The SUVmax of colorectal carcinoma was significantly higher in metastatic patients; the uptake of colorectal carcinoma was associated with LVD and the expression of HGF and VEGF-C but not with the expression of VEGFR-3. |
| Databáze: | OpenAIRE |
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