Fixed High-Dose Electroconvulsive Therapy in the Elderly With Depression
| Autor: | Sergio P. Rigonatti, Alberto Stoppe Jr., Mario Louzã, Gislaine Gil, Moacyr Alexandro Rosa |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Neuroscience (miscellaneous) behavioral disciplines and activities law.invention Electroconvulsive therapy Double-Blind Method Randomized controlled trial law mental disorders medicine Humans Electroconvulsive Therapy Psychiatry Adverse effect Depression (differential diagnoses) Aged Analysis of Variance Depressive Disorder Chi-Square Distribution Cognitive disorder Neuropsychology Middle Aged medicine.disease Psychiatry and Mental health Treatment Outcome Tolerability Anesthesia Female Psychology Chi-squared distribution |
| Zdroj: | The Journal of ECT. 22:92-99 |
| ISSN: | 1095-0680 |
| DOI: | 10.1097/00124509-200606000-00003 |
| Popis: | Objective To evaluate efficacy and tolerability of unilateral (RUL) and bilateral (BL) electroconvulsive therapy (ECT) in the elderly with depression. Methods Thirty-nine elderly inpatients with major depression referred to ECT were randomized into RUL or BL ECT, using high, fixed electrical doses. Cognition and depression severity were assessed before, during, and 1 month after treatment. Adverse effects were assessed after each session. Results Remission rates for RUL ECT (88.2%) and BL ECT (68.2%) were similar (P = 0.25). Reduction rates of depressive symptoms were also similar. There were no serious adverse events. There were more adverse effects in the BL ECT group (P = 0.05). BL ECT showed more short-term cognitive impairment, whereas improvements in neuropsychological scores were seen in both groups. Conclusion In elderly depressive subjects, high-dose RUL ECT is as effective as BL ECT yet produces less adverse effects and less cognitive impairment. |
| Databáze: | OpenAIRE |
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