Successful non-T-cell-depleted nonmyeloablative hematopoietic stem cell transplantation (NST) from an HLA-haploidentical 2-loci-mismatched sibling in a heavily transfused patient with severe aplastic anemia based on the fetomaternal microchimerism
| Autor: | N. Ehira, Hiroo Saji, Heiwa Kanamori, Nobuo Masauzi, M Yamada, Junji Tanaka, T Kawamura, Etsuko Maruya, S Obara, Takafumi Matsushima, Masahiro Imamura, Masahiro Asaka, T. Miura, S Saitoh, H. Yamato, N Ogura, Yutaka Tsutsumi |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_treatment T cell T-Lymphocytes Hematopoietic stem cell transplantation Human leukocyte antigen Neutropenia Haploidy Lymphocyte Depletion medicine Humans Transplantation Homologous Blood Transfusion Hemochromatosis Transplantation business.industry Histocompatibility Testing Siblings Hematopoietic stem cell Anemia Aplastic Microchimerism Hematology medicine.disease medicine.anatomical_structure Treatment Outcome Immunology Savior sibling business Stem Cell Transplantation |
| Zdroj: | Bone marrow transplantation. 34(3) |
| ISSN: | 0268-3369 |
| Popis: | A 37-year-old Japanese man with systemic hemochromatosis due to multiple transfusions was referred to us for the treatment of severe aplastic anemia (SAA), from which he had been suffering for 24 years. The patient had diabetes arising from the hemochromatosis, chronic anal fissures, and a kidney abscess due to neutropenia. He was treated with a nonmyeloablative preconditioning regimen followed by non-T-cell-depleted (non-TCD) allogeneic peripheral blood stem cell transplantation (PBSCT) from his human leukocyte antigen (HLA)-haploidentical 2-loci-mismatched sibling. Prompt engraftment of granulocytes and platelets was observed, and graft-versus-host disease was easy to control. Noninherited maternal antigens in the donor were confirmed prior to PBSCT, and they were also detected in small quantities in the recipient. This report describes the first successful nonmyeloablative hematopoietic stem cell transplant in a heavily transfused SAA patient from an HLA-haploidentical 2-loci-mismatched sibling donor. The result suggests that a long-term fetomaternal microchimerism-positive sibling can be a second-line donor if an alternative HLA-identical donor is not available. |
| Databáze: | OpenAIRE |
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