Hepatitis C Virus Epitope Immunodominance and B Cell Repertoire Diversity
| Autor: | Nicodemus Tedla, Rowena A. Bull, Andrew R. Lloyd, Anurag Adhikari, Nicholas A. Brasher |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Viral Hepatitis Vaccines
hepatitis C virus 0301 basic medicine Hepatitis C virus HCV–BCR interactions Hepacivirus Review Immunodominance Biology Immunoglobulin light chain medicine.disease_cause Microbiology Epitope 03 medical and health sciences 0302 clinical medicine Virology medicine Humans antigenic domains neutralising antibodies B-Lymphocytes immunodominance public antibody repertoire Immunodominant Epitopes Repertoire Rational design Antibodies Monoclonal virus diseases Hepatitis C Antibodies Antibodies Neutralizing Hepatitis C QR1-502 digestive system diseases epitope mapping 030104 developmental biology Infectious Diseases Epitope mapping vaccine development human monoclonal antibodies biology.protein 030211 gastroenterology & hepatology Antibody Broadly Neutralizing Antibodies |
| Zdroj: | Viruses Viruses, Vol 13, Iss 983, p 983 (2021) |
| ISSN: | 1999-4915 |
| Popis: | Despite the advent of effective, curative treatments for hepatitis C virus (HCV), a preventative vaccine remains essential for the global elimination of HCV. It is now clear that the induction of broadly neutralising antibodies (bNAbs) is essential for the rational design of such a vaccine. This review details the current understanding of epitopes on the HCV envelope, characterising the potency, breadth and immunodominance of antibodies induced against these epitopes, as well as describing the interactions between B-cell receptors and HCV infection, with a particular focus on bNAb heavy and light chain variable gene usage. Additionally, we consider the importance of a public repertoire for antibodies against HCV, compiling current knowledge and suggesting that further research in this area may be critical to the rational design of an effective HCV vaccine. |
| Databáze: | OpenAIRE |
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