Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway
| Autor: | Gunnstein Bakland, Richard A. Watts, Aksel Thuv Nilsen, Raashid Luqmani, Wenche Koldingsnes, Christine Karlsen |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Databases Factual Prevalence Microscopic Polyangiitis ANCA-Associated Vasculitis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Churg-Strauss Syndrome 03 medical and health sciences Northern norway Young Adult 0302 clinical medicine Rheumatology Catchment Area Health Internal medicine Epidemiology Medicine Humans Pharmacology (medical) Registries Aged 030203 arthritis & rheumatology business.industry Norway Incidence (epidemiology) Incidence Granulomatosis with Polyangiitis Middle Aged medicine.disease 030104 developmental biology Female business Microscopic polyangiitis Granulomatosis with polyangiitis Vasculitis Algorithms |
| Zdroj: | Rheumatology (Oxford, England). 59(9) |
| ISSN: | 1462-0332 |
| Popis: | Objective ANCA-associated vasculitides (AAV) have increased in prevalence since the 1980s. We aimed to investigate the incidence and prevalence of AAV during a 15-year period from 1999 to 2013 in Northern Norway, looking for variations during this period. Methods Patient records were retrieved from The Northern Norwegian Vasculitis Registry; in addition we searched all regional hospital databases. Patients diagnosed with AAV from 1999 through to 2013 were included. For prevalence data, patients residing in the area, but with AAV diagnosis prior to 1999, were also included. The diagnosis of AAV was based on the European Medicines Agency algorithm. Results We identified 140 cases; 88 were classified as granulomatosis with polyangiitis (GPA), 37 as microscopic polyangiitis (MPA) and 15 as eosinophilic granulomatosis with polyangiitis (EGPA). Adult (age ≥15 years) annual incidence rates per million were as follows: for GPA 15.6 (95% CI: 12.5, 19.2), MPA 6.5 (95% CI: 4.6, 9.0), EGPA 2.7 (95% CI: 1.5, 4.5) and overall AAV 24.7 (95% CI: 20.8, 29.2). Incidences of MPA and overall AAV showed an increasing trend (P Conclusion The incidence rate of GPA and the prevalence rates of GPA and EGPA are currently the highest reported. MPA increased significantly from a prior low incidence. The overall AAV annual incidence and prevalence are still increasing. |
| Databáze: | OpenAIRE |
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