Buccal Epithelium, Cigarette Smoking, and Lung Cancer: Review of the Literature
Autor: | Oleksandr Halytskyy, Ira A. Oliff, Nasir Saleem, Raya Saba |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Epithelium Cigarette Smoking 03 medical and health sciences 0302 clinical medicine Cigarette smoking Internal medicine medicine Noxious stimulus Humans Epigenetics Lung cancer Early Detection of Cancer Surrogate endpoint business.industry Smoking Mouth Mucosa General Medicine Buccal administration medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis business Lung cancer screening |
Zdroj: | Oncology. 93:347-353 |
ISSN: | 1423-0232 0030-2414 |
Popis: | Lung cancer is currently the leading cause of cancer-related mortality among men and women in the United States, and optimal screening methods are still lacking. The field effect is a well-supported phenomenon wherein a noxious stimulus triggers genetic, epigenetic and molecular changes that are widespread throughout the entire exposed organ system. The buccal epithelium is an easily accessible part of the respiratory tree that has good potential of yielding a surrogate marker for the field effect in cigarette smokers, and thus, a noninvasive, reliable lung cancer screening method. Herein, we review the literature on the relationship between the buccal epithelium, cigarette smoking, and lung cancer. |
Databáze: | OpenAIRE |
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