Pre- and post-transplant monitoring of soluble CD30 levels as predictor of acute renal allograft rejection
| Autor: | Zhang-Xin Zeng, Jian-ming Tan, Shun-liang Yang, Wei-zhen Wu, Guojun Wu, He Wang, Qinghua Wang, Dong Wang, Wen-hong Lin, Jin-Hua Chen |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty medicine.medical_treatment Immunology Renal graft Ki-1 Antigen Gastroenterology Cohort Studies Soluble cd30 Monitoring Immunologic Internal medicine medicine Humans Immunology and Allergy Pre and post Kidney transplantation Retrospective Studies Immunosuppression Therapy Transplantation business.industry Immunosuppression Retrospective cohort study Middle Aged Prognosis medicine.disease Kidney Transplantation Surgery Renal allograft Female business Cohort study |
| Zdroj: | Transplant Immunology. 17:278-282 |
| ISSN: | 0966-3274 |
| Popis: | Identification of renal graft candidates at high risk of impending acute rejection (AR) and graft loss may be helpful for patient-tailored immunosuppressive regimens and renal graft survival. To investigate the feasibility with soluble CD30 (sCD30) as predictor of AR, sCD30 levels of 70 patients were detected on day 0 pre-transplant and day 1, 3, 5, 7, 10, 14, 21, and 30 post-transplant. AR episodes in 6 months were recorded and then patients were divided into Group AR (n=11) and Group UC (n=59). Results showed that the patients had higher pre-transplant sCD30 levels than healthy people. A significant decrease of sCD30 was observed on the first day post-transplant and continued until day 14 post-transplant. Soluble CD30 presented a stable level from day 14 to 30 post-transplant. Pre-transplant sCD30 levels of Group AR were much higher than those of Group UC (P |
| Databáze: | OpenAIRE |
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